Preterm Twins Born to a Mother with Miliary Tuberculosis: Importance of Early Recognition and Prompt Response in Infection Control to Manage Congenital Tuberculosis Exposure in a Neonatal Intensive Care Unit
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- Ryu Byung-Han
- Department of Infectious Diseases, Gyeongsang National University Changwon Hospital, Republic of Korea
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- Baek Eun-Hwa
- Infection Control Office, Gyeongsang National University Changwon Hospital, Republic of Korea
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- Kim Da-Hye
- Infection Control Office, Gyeongsang National University Changwon Hospital, Republic of Korea
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- Kim Se-Eun
- Infection Control Office, Gyeongsang National University Changwon Hospital, Republic of Korea
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- Kim Hyun-Ju
- Infection Control Office, Gyeongsang National University Changwon Hospital, Republic of Korea
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- Cho Oh-Hyun
- Department of Infectious Diseases, Gyeongsang National University Changwon Hospital, Republic of Korea
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- Hong Sun In
- Department of Infectious Diseases, Gyeongsang National University Changwon Hospital, Republic of Korea
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- Do Hyun-Jeong
- Department of Pediatrics, Gyeongsang National University Changwon Hospital, Republic of Korea
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- Park Chan-Hoo
- Department of Pediatrics, Gyeongsang National University Changwon Hospital, Republic of Korea
この論文をさがす
抄録
<p>Delayed diagnosis of congenital tuberculosis (TB) in the neonatal intensive care unit (NICU) is a serious problem in terms of infection control. Here, we report our preemptive infection control activities implemented after the diagnosis of miliary TB in a mother of preterm twins (index twins, NB1 and NB2) in the NICU. In addition, we reviewed previous case reports of congenital TB exposure in the NICU setting. Immediately after diagnosing miliary TB in the mother, the index twins were isolated before their TB diagnosis and received preemptive anti-TB medication; contact investigations were also conducted. Eventually, NB1 was diagnosed with congenital TB at 29 days of age, and NB2 showed no definite evidence of TB. Through contact investigation, 11 of the 16 exposed infants received isoniazid prophylaxis and no positive tuberculin skin test results were obtained after 3 months. One of the 31 exposed healthcare workers showed new interferon-gamma release assay conversion. Moreover, our case showed a much shorter contagious period compared to that in previous reports (8 versus 17–102 days). This suggests that a high index of suspicion and prompt measures can help prevent congenital TB outbreaks and reduce the burden of infection control activities in the NICU.</p>
収録刊行物
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- Japanese Journal of Infectious Diseases
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Japanese Journal of Infectious Diseases 74 (2), 97-101, 2021-03-31
国立感染症研究所 Japanese Journal of Infectious Diseases 編集委員会
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詳細情報 詳細情報について
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- CRID
- 1390287454979052160
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- NII論文ID
- 130008002374
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- NII書誌ID
- AA1132885X
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- ISSN
- 18842836
- 13446304
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- NDL書誌ID
- 031391703
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- PubMed
- 32741929
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可