Serum Albumin and Risks of Stroke and Its Subtypes ― The Circulatory Risk in Communities Study (CIRCS) ―
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- Li Jiaqi
- Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine
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- Imano Hironori
- Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine Osaka Center for Cancer and Cardiovascular Disease Prevention
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- Yamagishi Kazumasa
- Osaka Center for Cancer and Cardiovascular Disease Prevention Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba Ibaraki Western Medical Center
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- Cui Renzhe
- Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine
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- Muraki Isao
- Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine Osaka Center for Cancer and Cardiovascular Disease Prevention
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- Umesawa Mitsumasa
- Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba Department of Public Health, Dokkyo Medical University School of Medicine
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- Hayama-Terada Mina
- Osaka Center for Cancer and Cardiovascular Disease Prevention Yao City Public Health Center
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- Ohira Tetsuya
- Department of Epidemiology, Fukushima Medical University
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- Kiyama Masahiko
- Osaka Center for Cancer and Cardiovascular Disease Prevention
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- Okada Takeo
- Osaka Center for Cancer and Cardiovascular Disease Prevention
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- Sankai Tomoko
- Department of Community Health, Faculty of Medicine, University of Tsukuba
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- Tanigawa Takeshi
- Department of Public Health, Juntendo University School of Medicine
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- Kitamura Akihiko
- Osaka Center for Cancer and Cardiovascular Disease Prevention Research Team for Social Participation and Community Health, Tokyo Metropolitan Institute of Gerontology
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- Iso Hiroyasu
- Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba
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Abstract
<p>Background:Few studies have investigated the association between serum albumin levels and the risk of stroke subtypes among the general Japanese population.</p><p>Methods and Results:In this study, 5,071 men and 7,969 women aged 40–74 years, initially free from stroke, coronary artery disease, and kidney and hepatic failure, and residing in 4 Japanese communities completed a baseline risk factor survey between 1985 and 1994. During the 24-year follow-up, 528 men and 553 women experienced stroke. In the entire study cohort, multivariable hazard ratios (HRs) and 95% confidence intervals (CIs) of total stroke, ischemic stroke, and intracerebral hemorrhage for the lowest vs. highest quartiles of serum albumin were 1.45 (1.18–1.77), 1.52 (1.17–1.97), and 1.57 (1.04–2.37), respectively. In men, multivariable HRs (95% CIs) for total stroke, ischemic stroke, and intracerebral hemorrhage in the lowest vs. highest serum albumin quartile were 1.44 (1.07–1.92), 1.48 (1.03–2.11) and 1.71 (0.92–3.18), respectively, whereas in women they were 1.50 (1.13–1.99), 1.63 (1.11–2.39), and 1.56 (0.89–2.74), respectively. Similar inverse associations were observed for each of the ischemic stroke subtypes, but not for subarachnoid hemorrhage.</p><p>Conclusions:Low serum albumin levels were associated with an increased risk of total stroke, ischemic stroke, ischemic stroke subtypes, and intracerebral hemorrhage.</p>
Journal
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- Circulation Journal
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Circulation Journal 85 (4), 385-392, 2021-03-25
The Japanese Circulation Society
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Keywords
Details 詳細情報について
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- CRID
- 1390850412752945280
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- NII Article ID
- 130008003056
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- NII Book ID
- AA11591968
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- ISSN
- 13474820
- 13469843
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- HANDLE
- 2241/0002004959
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- NDL BIB ID
- 031363908
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- PubMed
- 33191391
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- Text Lang
- en
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- Data Source
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- JaLC
- IRDB
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed