A Pilot Study Investigating the Use of Regional Oxygen Saturation as a Predictor of Ischemic Wound Healing Outcome after Endovascular Treatment in Patients with Chronic Limb-Threatening Ischemia

• Kayama Takafumi

  Division of Vascular Surgery, Hamamatsu University School of Medicine Second Department of Surgery, Hamamatsu University School of Medicine

• Sano Masaki

  Division of Vascular Surgery, Hamamatsu University School of Medicine Second Department of Surgery, Hamamatsu University School of Medicine

• Inuzuka Kazunori

  Division of Vascular Surgery, Hamamatsu University School of Medicine Second Department of Surgery, Hamamatsu University School of Medicine

• Katahashi Kazuto

  Division of Vascular Surgery, Hamamatsu University School of Medicine Second Department of Surgery, Hamamatsu University School of Medicine

• Yata Tatsuro

  Division of Vascular Surgery, Hamamatsu Medical Center

• Yamanaka Yuta

  Division of Vascular Surgery, Hamamatsu University School of Medicine Second Department of Surgery, Hamamatsu University School of Medicine

• Naruse Ena

  Division of Vascular Surgery, Hamamatsu University School of Medicine Second Department of Surgery, Hamamatsu University School of Medicine

• Yamamoto Naoto

  Division of Vascular Surgery, Hamamatsu Medical Center

• Takeuchi Hiroya

  Second Department of Surgery, Hamamatsu University School of Medicine

• Unno Naoki

  Division of Vascular Surgery, Hamamatsu University School of Medicine Second Department of Surgery, Hamamatsu University School of Medicine Division of Vascular Surgery, Hamamatsu Medical Center

Abstract

Objective: To determine the prognostic value of regional tissue oxygenation saturation (rSO₂) for ulcer healing after endovascular treatment (EVT) of peripheral arterial disease (PAD). Materials and Methods: Among PAD patients, 34 patients with chronic limb-threatening ischemia underwent EVT for limb salvage. We retrospectively analyzed the cutoff rSO₂ values on postoperative day 1 to predict ulcer healing and patient prognosis. Skin perfusion pressure (SPP) and transcutaneous oxygen pressure (TcPO₂) were also used to assess wound healing. Results: A finger-mounted tissue oximeter can easily measure rSO₂ on the dorsal foot. Among the 34 patients, the ulcer healed in 25, and no changes were observed in 2 patients at 1 month after EVT. However, 7 patients needed major amputation at the same time. Wound healing was achieved in all patients with rSO₂≥50%. With this cutoff, the sensitivity and specificity of the new device for wound healing were 100% and 64%, respectively. In all the wound healing cases, SPP was ≥45 mmHg, and TcPO₂ was ≥40 mmHg. Conclusion: To assess limb ischemia, rSO₂ can be measured quickly and easily using this device. We suggest that an rSO₂>50% shows good prognosis for ulcer healing.

Journal

• Annals of Vascular Diseases

  Annals of Vascular Diseases 14 (1), 23-30, 2021-03-25

  The Editorial Committee of Annals of Vascular Diseases

Keywords

• pilot study
• oximetry
• near-infrared spectroscopy
• ischemia
• wound healing

Details

• CRID: 1390287462800326784
• NII Article ID: 130008003240
• DOI: 10.3400/avd.oa.20-00132
• ISSN: 18816428
• ISSN: 1881641X
• Web Site: https://www.jstage.jst.go.jp/article/avd/14/1/14_oa.20-00132/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2022006709
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed