Recent Researches on Transdermal Drug Delivery by Emulsions – Focusing on Utilizing Transdermal Enhancers and Ionic Liquids –

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  • Kozaka Shuto
    Department of Applied Chemistry, Faculty of Engineering, Kyushu University
  • Hara Koki
    Department of Applied Chemistry, Faculty of Engineering, Kyushu University
  • Goto Masahiro
    Department of Applied Chemistry, Faculty of Engineering, Kyushu University Center for Future Chemistry, Kyushu University Advanced Transdermal Drug Delivery System Center, Kyushu University

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  • エマルションによる経皮薬物送達技術の最新研究 – 経皮吸収促進剤とイオン液体の利用を中心に–
  • エマルション ニ ヨル ケイヒ ヤクブツ ソウタツ ギジュツ ノ サイシン ケンキュウ : ケイヒ キュウシュウ ソクシンザイ ト イオン エキタイ ノ リヨウ オ チュウシン ニ

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Abstract

Transdermal drug delivery, in which drugs are administered through the skin, has been attracting much attention because it can bypass the first–pass effect in the liver, maintain the effective drug concentration in blood, avoid the pain and the risks of accidents in injection. Since the skin plays an important role as a barrier preventing the entry of foreign substances from the outside, a special technique is required to achieve the effective transdermal delivery of drugs. In this review, we introduce the latest transdermal drug delivery systems using emulsions. The use of emulsions enables to deliver high–molecular–weight drugs, which are usually difficult to permeate through the skin. Emulsions combined with a skin enhancer or ionic liquids are found to be useful for the effective transdermal delivery of biomolecules such as peptides or proteins.

Journal

  • MEMBRANE

    MEMBRANE 46 (2), 91-97, 2021

    THE MEMBRANE SOCIETY OF JAPAN

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