A Pilot Evaluation Study of Diffuse Coronary Arterial Contraction Causing Ischemia by Double Measurement of Left Ventriculography Before and After Intracoronary Administration of Nitrates

• Minai Kosuke

  Division of Cardiology, Department of Internal Medicine, The Jikei University School of Medicine

• Kawai Makoto

  Division of Cardiology, Department of Internal Medicine, The Jikei University School of Medicine

• Ogawa Kazuo

  Division of Cardiology, Department of Internal Medicine, The Jikei University School of Medicine

• Nagoshi Tomohisa

  Division of Cardiology, Department of Internal Medicine, The Jikei University School of Medicine

• Morimoto Satoshi

  Division of Cardiology, Department of Internal Medicine, The Jikei University School of Medicine

• Inoue Yasunori

  Division of Cardiology, Department of Internal Medicine, The Jikei University School of Medicine

• Tanaka Toshikazu D.

  Division of Cardiology, Department of Internal Medicine, The Jikei University School of Medicine

• Komukai Kimiaki

  Division of Cardiology, Department of Internal Medicine, Kashiwa Hospital, The Jikei University School of Medicine

• Ogawa Takayuki

  Division of Cardiology, Department of Internal Medicine, The Jikei University School of Medicine

• Yoshimura Michihiro

  Division of Cardiology, Department of Internal Medicine, The Jikei University School of Medicine

Abstract

Background:Abnormal diffuse coronary artery contraction is not easily diagnosed. In order to evaluate its true risk, we performed double left ventriculography (LVG) before and after intracoronary administration of isosorbide dinitrate (ISDN). We also investigated the relationship between changes in coronary lumen area and changes in left ventricular ejection fraction (LVEF) after ISDN. Methods and Results:The study included 53 patients who underwent an acetylcholine (ACh) provocation test after coronary angiogram and LVG. The second LVG was performed after intracoronary ISDN administration. Coronary lumen area was measured by quantitative coronary arteriography (QCA). Simple and multiple regression analyses showed a significant correlation between changes in total QCA area before and after ISDN administration (pre-and post-total QCA area, respectively) and changes in LVEF. Using structural equation modeling, we observed a negative effect of pre-total QCA area and a positive effect of post-total QCA area on LVEF improvement. Importantly, LVEF improvement was similar between the ACh-positive and -negative groups on the coronary artery spasm test. Receiver operating characteristic curves indicated that the cut-off value at which changes in total QCA area affected changes in LVEF was 5%. Conclusions:Performing double LVG tests before and after ISDN administration may detect myocardial ischemia caused by diffuse coronary artery contraction. The addition of this method to the conventional ACh provocation test may detect the presence of local and/or global myocardial ischemia.

Journal

• Circulation Reports

  Circulation Reports 3 (4), 241-248, 2021-04-09

  The Japanese Circulation Society

Keywords

• Coronary artery spasm
• Double left ventriculography
• New approach

Details

• CRID: 1390569103977193600
• NII Article ID: 130008023441
• DOI: 10.1253/circrep.cr-21-0015
• ISSN: 24340790
• Web Site: https://www.jstage.jst.go.jp/article/circrep/3/4/3_CR-21-0015/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2021344957
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed