Role of intracellular zinc in molecular and cellular function in allergic inflammatory diseases

• Suzuki Masanobu

  Department of Otolaryngology-Head and Neck Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University Department of Surgery–Otorhinolaryngology Head and Neck Surgery, The Queen Elizabeth Hospital, The University of Adelaide

• Suzuki Takayoshi

  Department of Otolaryngology-Head and Neck Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University

• Watanabe Masashi

  Department of Biochemistry, Faculty of Medicine and Graduate School of Medicine, Hokkaido University

• Hatakeyama Shigetsugu

  Department of Biochemistry, Faculty of Medicine and Graduate School of Medicine, Hokkaido University

• Kimura Shogo

  Department of Otolaryngology-Head and Neck Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University

• Nakazono Akira

  Department of Otolaryngology-Head and Neck Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University

• Honma Aya

  Department of Otolaryngology-Head and Neck Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University

• Nakamaru Yuji

  Department of Otolaryngology-Head and Neck Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University

• Vreugde Sarah

  Department of Surgery–Otorhinolaryngology Head and Neck Surgery, The Queen Elizabeth Hospital, The University of Adelaide

• Homma Akihiro

  Department of Otolaryngology-Head and Neck Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University

抄録

Zinc is an essential micronutrient in human body and a vital cofactor for the function of numerous proteins encoded by the human genome. Zinc has a critical role in maintaining many biochemical and physiological processes at the molecular, cellular, and multiple organ and systemic levels. The alteration of zinc homeostasis causes dysfunction of many organs and systems. In the immune system, zinc regulates the differentiation, proliferation and function of inflammatory cells, including T cells, eosinophils, and B cells, by modifying several signaling pathways such as NFκB signaling pathways and TCR signals. An adequate zinc level is essential for proper immune responses and decreased zinc levels were reported in many allergic inflammatory diseases, including atopic dermatitis, bronchial asthma, and chronic rhinosinusitis. Decreased zinc levels often enhance inflammatory activation. On the other hand, the inflammatory conditions alter the intracellular homeostasis of zinc, often decreasing zinc levels. These findings implied that there could be a vicious cycle between zinc deficiency and inflammatory conditions. In this review, we present recent evidence on the involvement of zinc in atopic dermatitis, bronchial asthma, and chronic rhinosinusitis, with insights into the involvement of zinc in the underlying molecular and cellular mechanisms related to these allergic inflammatory diseases.

収録刊行物

• Allergology International

  Allergology International 70 (2), 190-200, 2021

  一般社団法人日本アレルギー学会

キーワード

• Atopic dermatitis
• Bronchial asthma
• Chronic rhinosinusitis
• Nasal polyps
• Zinquin

詳細情報

• CRID: 1390287685102799744
• NII論文ID: 130008024307
• DOI: 10.1016/j.alit.2020.09.007
• ISSN: 14401592
• ISSN: 13238930
• Web Site: https://api.elsevier.com/content/article/PII:S1323893020301337?httpAccept=text/xml
• Web Site: https://api.elsevier.com/content/article/PII:S1323893020301337?httpAccept=text/plain
• Web Site: https://search.jamas.or.jp/link/ui/2022048992
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
  • KAKEN
• 抄録ライセンスフラグ: 使用不可