Recent Progress in Structure-Activity Relationship Studies on Antitumor Macrolide Aplyronine A by Using Hybridization of Actin-depolymerizing Natural Product

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  • Takayuki Ohyoshi
    Department of Chemistry, Graduate School of Pure and Applied Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8571 , Japan
  • Hideo Kigoshi
    Department of Chemistry, Graduate School of Pure and Applied Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8571 , Japan

Abstract

<jats:title>Abstract</jats:title> <jats:p>Aplyronine A, an antitumor marine macrolide, has a novel mode of action, inducing the protein-protein interaction between two major cytoskeletons, actin and tubulin. This review discusses recent progress in the design of artificial analogs including hybridization and structure-activity relationship studies of aplyronine A.</jats:p>

Journal

  • Chemistry Letters

    Chemistry Letters 50 (4), 580-584, 2020-12-23

    Oxford University Press (OUP)

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