A cross-sectional analysis from the Mykinso Cohort Study: establishing reference ranges for Japanese gut microbial indices

DOI Web Site 被引用文献5件 参考文献57件
  • WATANABE Satoshi
    Cykinso, Inc., 1-36-1 Yoyogi, Shibuya, Tokyo 151-0053, Japan
  • KAMEOKA Shoichiro
    Cykinso, Inc., 1-36-1 Yoyogi, Shibuya, Tokyo 151-0053, Japan
  • SHINOZAKI Natsuko O.
    Cykinso, Inc., 1-36-1 Yoyogi, Shibuya, Tokyo 151-0053, Japan
  • KUBO Ryuichi
    Cykinso, Inc., 1-36-1 Yoyogi, Shibuya, Tokyo 151-0053, Japan
  • NISHIDA Akifumi
    Cykinso, Inc., 1-36-1 Yoyogi, Shibuya, Tokyo 151-0053, Japan Department of Electrical Engineering and Bioscience, Waseda University, 1-104 Totsuka, Shinjuku-ku, Tokyo 169-8050, Japan School of Computing, Tokyo Institute of Technology, 2-12-1 Okayama, Meguro-ku, Tokyo 152-8550, Japan
  • KURIYAMA Minoru
    Cykinso, Inc., 1-36-1 Yoyogi, Shibuya, Tokyo 151-0053, Japan
  • TAKEDA Aya K.
    Cykinso, Inc., 1-36-1 Yoyogi, Shibuya, Tokyo 151-0053, Japan

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<p>The purpose of this study was to establish reference ranges for gut microbial indices by collecting real-world Japanese microbiome data from a Mykinso cohort. Although several large cohort studies have focused on the human gut microbiome, large cohort studies of the gut microbiome from Japanese populations are scarce, especially from healthy or non-diseased individuals. We collected stool samples and original survey lifestyle information from 5,843 Japanese individuals through the Mykinso gut microbiome testing service. From the obtained 16S rRNA sequence data derived from stool samples, the ratio and distribution of each taxon were analyzed. The relationship between different epidemiological attributes and gut microbial indicators were statistically analyzed. The qualitative and quantitative indicators of these common gut microbiota were confirmed to be strongly correlated with age, sex, constipation/diarrhea, and history of lifestyle-related diseases. Therefore, we set up a healthy sub-cohort that controlled for these attribute factors and defined reference ranges from the distribution of gut microbial index in that population. Taken together, these results show that the gut microbiota of Japanese people had high beta-diversity, with no single “typical” gut microbiota type. We believe that the reference ranges for the gut microbial indices obtained in this study can be new reference values for determining the balance and health of the gut microbiota of an individual. In the future, it is necessary to clarify the clinical validity of these reference values by comparing them with a clinical disease cohort.</p>

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