Challenges to Creation of Artificial Organelle for Effective Editing of Cell Function

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  • Kishimura Akihiro
    Department of Applied Chemistry, Faculty of Engineering, Kyushu University Center for Molecular Systems, Kyushu University

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  • 細胞機能編集に向けた人工オルガネラ創製へのチャレンジ
  • Symposium Review 細胞機能編集に向けた人工オルガネラ創製へのチャレンジ
  • Symposium Review サイボウ キノウ ヘンシュウ ニ ムケタ ジンコウ オルガネラ ソウセイ エ ノ チャレンジ

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Abstract

<p>In “cell-function editing”, the combination of biological methods with artificial methods is a promising way to effectively implement functions that live cells do not originally possess. In the present symposium review, two approaches with methodology of building “artificial organelle” were implemented for editing cellular functions. One approach is the “membrane-bound artificial organelle”, which is mainly created from polymeric nanocapsules that function in cells, and the other approach mimics the “membraneless organelle”, which has recently gained immense interest in the field of cell biology. Furthermore, some examples of artificial cells are also described, which were constructed by utilizing artificial organelles. In this context, some recent progress has been observed in the author's research on the development of polyion complex (PIC) materials, in particular, PICsome-based nanoreactors, designer coacervates for protein sequestration, and yolk-shell PIC structures that are reminiscent of artificial cells. These technologies may contribute to effective “cell editing” or “cell renovation”, which enables the edited cells to show higher performance at the target site in the human body, compared to the native cells.</p>

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 141 (5), 625-633, 2021-05-01

    The Pharmaceutical Society of Japan

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