立体培養法を利用した疾患微小環境モデルの開発と病態解析

• 田中 啓祥

  岡山大学大学院医歯薬学総合研究科医薬品臨床評価学

書誌事項

タイトル別名

• Modeling and Analysis of Disease Microenvironments with 3D Cell Culture Technology
• Symposium Review 立体培養法を利用した疾患微小環境モデルの開発と病態解析
• Symposium Review リッタイ バイヨウホウ オ リヨウ シタ シッカン ビショウ カンキョウ モデル ノ カイハツ ト ビョウタイ カイセキ

抄録

Remarkable progress in our ability to analyze diseased tissue has revolutionized our understanding of disease. From a simplistic understanding of abnormalities in bulk tissue, there is now increasing recognition that the heterogeneous and dynamically evolving disease microenvironment plays a crucial role in disease pathogenesis and progression as well as in the determination of therapeutic response. The disease microenvironment consists of multiple cell types as well as the various factors that these cells secrete. There is now immense interest in treatment strategies that target or modify the abnormal disease microenvironment, and a deeper understanding of the mechanisms that drive the formation, maintenance, and progression of the disease microenvironment is thus necessary. The advent of 3-dimensional (3D) cell culture technology has made possible the reconstitution of the disease microenvironment to a previously unimaginable extent in vitro. As an intermediate between traditional in vitro models based on 2-dimensional (2D) cell culture and in vivo models, 3D models of disease enable the in vitro reconstitution of complex interactions within the disease microenvironment which were unamenable in 2D while simultaneously allowing the mechanistic analysis of these interactions that would be difficult to perform in vivo. This symposium review aims to highlight the promise of using 3D cell culture technology to model and analyze the disease microenvironment using pancreatic cancer as an example.

収録刊行物

• 薬学雑誌

  薬学雑誌 141 (5), 647-653, 2021-05-01

  公益社団法人 日本薬学会

キーワード

• 3-dimensional cell culture
• disease model
• disease microenvironment

詳細情報

• CRID: 1390569382246408704
• NII論文ID: 130008032743
• NII書誌ID: AN00284903
• DOI: 10.1248/yakushi.20-00219-4
• ISSN: 13475231
• ISSN: 00316903
• NDL書誌ID: 031499088
• PubMed: 33952746
• Web Site: http://id.ndl.go.jp/bib/031499088
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I031499088
• Web Site: https://www.jstage.jst.go.jp/article/yakushi/141/5/141_20-00219-4/_pdf
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• 抄録ライセンスフラグ: 使用不可