Single Particle Tracking Analysis of Optical Trapping Dynamics of AMPA-type Glutamate Receptors

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  • Kishimoto Tatsunori
    Department of Chemistry, Graduate School of Science, Osaka City University Department of Human System Interaction, Graduate School of Science and Technology, Kwansei Gakuin University
  • Kudoh Suguru N.
    Department of Human System Interaction, Graduate School of Science and Technology, Kwansei Gakuin University
  • Taguchi Takahisa
    Center for Information and Neural Networks, National Institute of Information and Communications Technology (NICT)
  • Hosokawa Chie
    Department of Chemistry, Graduate School of Science, Osaka City University Advanced Photonics and Biosensing Open Innovation Laboratory, National Institute of Advanced Industrial Science and Technology (AIST)

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  • 神経細胞表面におけるAMPA型グルタミン酸受容体分子の光捕捉過程
  • シンケイ サイボウ ヒョウメン ニ オケル AMPAガタ グルタミンサン ジュヨウタイ ブンシ ノ ヒカリ ホソク カテイ

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Abstract

<p>AMPA-type glutamate receptor (AMPAR) is one of neurotransmitter receptors at excitatory synapses in neurons. For realizing the artificial control of synaptic transmission, we have applied optical trapping of quantum-dot (QD) conjugated AMPARs on neurons. Here, we evaluate optical trapping dynamics of QD-AMPARs on neurons by single particle tracking (SPT) analysis. The diffusion coefficient derived from mean square displacement (MSD) at laser focus of QD-AMPARs on neurons decreased with the laser irradiation and the culturing days, which suggests that the molecular dynamics of QD-AMPARs are constrained at the focal spot due to optical trapping forces.</p>

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