Eosinophilic esophagitis and asymptomatic esophageal eosinophilia display similar immunohistological profiles
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- Kitamura Hiroyuki
- Department of Gastroenterology, Osaka City University Graduate School of Medicine
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- Tanaka Fumio
- Department of Gastroenterology, Osaka City University Graduate School of Medicine
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- Nadatani Yuji
- Department of Gastroenterology, Osaka City University Graduate School of Medicine
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- Otani Koji
- Department of Gastroenterology, Osaka City University Graduate School of Medicine
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- Hosomi Shuhei
- Department of Gastroenterology, Osaka City University Graduate School of Medicine
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- Kamata Noriko
- Department of Gastroenterology, Osaka City University Graduate School of Medicine
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- Taira Koichi
- Department of Gastroenterology, Osaka City University Graduate School of Medicine
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- Nagami Yasuaki
- Department of Gastroenterology, Osaka City University Graduate School of Medicine
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- Tanigawa Tetsuya
- Department of Gastroenterology, Osaka City University Graduate School of Medicine
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- Fukumoto Shinya
- Department of Premier Preventive Medicine, Osaka City University Graduate School of Medicine
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- Watanabe Toshio
- Department of Gastroenterology, Osaka City University Graduate School of Medicine
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- Kawada Norifumi
- Department of Premier Preventive Medicine, Osaka City University Graduate School of Medicine Department of Hepatology, Osaka City University Graduate School of Medicine
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- Fujiwara Yasuhiro
- Department of Gastroenterology, Osaka City University Graduate School of Medicine
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<p>Patients with asymptomatic esophageal eosinophilia (aEE) do not exhibit clinical symptoms because of esophageal dysfunction, although they have endoscopic and histological findings similar to those of eosinophilic esophagitis (EoE). The cause of the symptoms and the differences between aEE and EoE are unclear. The aim of this study is to determine whether aEE and EoE are same disease entities by comparing immune-related tissue biomarkers using immunohistological staining. Esophageal biopsy specimens from 61 patients, including 18 with aEE and 43 with EoE, were analyzed. Immunofluorescence staining was performed to quantify the immune-related tissue biomarkers such as major basic protein, eosinophil-derived neurotoxin, eotaxin-3, and immunoglobulin G4. Data are presented as median (interquartile range). There were no significant differences in clinical, endoscopic, or histological features, between patients with aEE and EoE, with the exception of body mass index. There were no significant differences in all immune-related tissue biomarkers between both groups. In conclusions, EoE and aEE displayed similar immunohistological profiles. Hence, they may be similar disease entities with some common pathogenic mechanisms. Our findings suggest that patients with aEE also have histopathological esophageal inflammation.</p>
収録刊行物
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- Journal of Clinical Biochemistry and Nutrition
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Journal of Clinical Biochemistry and Nutrition 68 (3), 246-252, 2021-05-01
一般社団法人 日本酸化ストレス学会
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詳細情報 詳細情報について
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- CRID
- 1390569382247945216
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- NII論文ID
- 130008033292
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- ISSN
- 18805086
- 09120009
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
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- 使用不可