The Amount of Residual Incretin Regulates the Pancreatic β-cell Function and Glucose Homeostasis
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- Kondo Tatsuya
- Department of Diabetes, Metabolism and Endocrinology, Kumamoto University Hospital, Japan
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- Kitano Sayaka
- Department of Diabetes, Metabolism and Endocrinology, Kumamoto University Hospital, Japan
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- Miyakawa Nobukazu
- Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Japan
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- Watanabe Takuro
- Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Japan
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- Goto Rieko
- Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Japan
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- Sato Miki
- Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Japan
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- Hanatani Satoko
- Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Japan
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- Sakaguchi Masaji
- Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Japan
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- Igata Motoyuki
- Department of Diabetes, Metabolism and Endocrinology, Kumamoto University Hospital, Japan
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- Kawashima Junji
- Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Japan
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- Motoshima Hiroyuki
- Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Japan
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- Matsumura Takeshi
- Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Japan
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- Araki Eiichi
- Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Japan
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抄録
<p>The gastrointestinal tract is considered an important endocrine organ for controlling glucose homeostasis via the production of incretins. A 21-year-old man emergently underwent total colectomy due to severe ulcerative colitis, and overt diabetes became evident. Weekly administration of a glucagon-like peptide (GLP)-1 receptor agonist (RA) dramatically improved his glucose control. Levels of GLP-1 or gastric inhibitory polypeptide (GIP) were low at the baseline in the duodenum and serum of the patient. After 11 months of GLP-1RA treatment, his HbA1c worsened again, and intensive insulin therapy was necessary to control his glucose levels. Our report may explain the significance of residual incretin for maintaining the pancreatic β-cell function. </p>
収録刊行物
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- Internal Medicine
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Internal Medicine 60 (9), 1433-1442, 2021-05-01
一般社団法人 日本内科学会
