Effects of enflurane on cardiac autonomic nervous activity in mice

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  • Ogata Yoshiki
    Department of Pharmacology, Hirosaki University Graduate School of Medicine
  • Yonekura Manabu
    Department of Cardiology and Nephrology, Hirosaki University Graduate School of Medicine
  • Yamaki Rouichi
    Department of Pharmacology, Hirosaki University Graduate School of Medicine
  • Han Chong
    Department of Pharmacology, Hirosaki University Graduate School of Medicine
  • Fujiwara Tomonori
    Department of Pharmacology, Hirosaki University Graduate School of Medicine
  • Seya Kazuhiko
    Department of Pharmacology, Hirosaki University Graduate School of Medicine
  • Niwa Hidetoshi
    Department of Anesthesiology, Hirosaki University Graduate School of Medicine
  • Kushikata Tetsuya
    Department of Anesthesiology, Hirosaki University Graduate School of Medicine
  • Imaizumi Tadaatsu
    Department of Vascular Biology, Institute of Brain Science, Hirosaki University, Graduate School of Medicine
  • Hirota Kazuyoshi
    Department of Anesthesiology, Hirosaki University Graduate School of Medicine
  • Tomita Hirofumi
    Department of Cardiology and Nephrology, Hirosaki University Graduate School of Medicine
  • Murakami Manabu
    Department of Pharmacology, Hirosaki University Graduate School of Medicine

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Abstract

We examined the effects of enflurane anesthesia on the mouse cardiac autonomic nervous system using electrocardiogram (ECG) analysis. Enflurane had a lower effect on heart rate (HR) compared to isoflurane, which is more widely used in small animal studies. Under anesthesia with 3 or 4% of enflurane, administration of propranolol had a significant effect on HR. Enflurane increased R-R interval length in a dose-dependent fashion, and the R-R interval became unstable at high concentrations. Although HR decreased with high doses of enflurane, we observed normal sinus rhythm and no arrhythmia. These results suggest that the effect of enflurane anesthesia is acceptable even though the drug can lead to cardiac instability. No remarkable changes were observed in HR frequency. These results suggest that enflurane anesthesia may be suitable for cardiac autonomic nervous system analysis.

Journal

  • Hirosaki Medical Journal

    Hirosaki Medical Journal 67 (2-4), 153-157, 2017

    Hirosaki University Graduate School of Medicine,Hirosaki Medical Society

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