Relationship Between Fasting Blood Glucose Levels in Middle Age and Cognitive Function in Later Life: The Aichi Workers’ Cohort Study
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- Shimoda Masako
- Department of Public Health and Health Systems, Nagoya University Graduate School of Medicine
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- Kaneko Kayo
- Department of Occupational and Environmental Health, Graduate School of Medical Sciences, Nagoya City University
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- Nakagawa Takeshi
- National Center for Geriatrics and Gerontology
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- Kawano Naoko
- Osaka Prefecture University
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- Otsuka Rei
- National Center for Geriatrics and Gerontology
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- Ota Atsuhiko
- Department of Public Health, Fujita Health University School of Medicine
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- Naito Hisao
- Department of Public Health, Fujita Health University School of Medicine
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- Matsunaga Masaaki
- Department of Public Health, Fujita Health University School of Medicine
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- Ichino Naohiro
- Department of Public Health, Fujita Health University School of Medicine
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- Yamada Hiroya
- Department of Public Health, Fujita Health University School of Medicine
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- Chiang Chifa
- Department of Public Health and Health Systems, Nagoya University Graduate School of Medicine
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- Hirakawa Yoshihisa
- Department of Public Health and Health Systems, Nagoya University Graduate School of Medicine
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- Tamakoshi Koji
- Department of Nursing, Nagoya University School of Health Sciences
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- Aoyama Atsuko
- Nagoya University of Arts and Sciences
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- Yatsuya Hiroshi
- Department of Public Health and Health Systems, Nagoya University Graduate School of Medicine Department of Public Health, Fujita Health University School of Medicine
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Abstract
<p>Background: There is limited evidence regarding the relationship between Diabetes mellitus (DM) in middle age and mild cognitive impairment after a follow-up. Therefore, we investigated the relationship between fasting blood glucose (FBG) levels in middle age and cognitive function assessed using the Japanese version of the Montreal Cognitive Assessment (MoCA-J) in later life, following over 15 years of follow-up in the Aichi Workers’ Cohort Study in Japan.</p><p>Methods: Participants were 253 former local government employees aged 60–79 years in 2018 who participated in a baseline survey conducted in 2002. Using baseline FBG levels and self-reported history, participants were classified into the normal, impaired fasting glucose (IFG) and, and DM groups. Total MoCA-J score ranges from 0 to 30, and cognitive impairment was defined as MoCA-J score ≤25 in this study. A general linear model was used to estimate the mean MoCA-J scores in the FBG groups, adjusted for age, sex, educational year, smoking status, alcohol consumption, physical activity, body mass index, systolic blood pressure, total cholesterol, and estimated glomerular filtration rate.</p><p>Results: The mean MoCA-J score in the total population was 25.0, and the prevalence of MoCA-J score ≤25 was 49.0%. Multivariable-adjusted total MoCA-J scores were 25.2, 24.8, and 23.4 in the normal, IFG, and DM groups, respectively. The odds ratio of MoCA-J score ≤25 in the DM group was 3.29.</p><p>Conclusion: FBG level in middle age was negatively associated with total MoCA-J scores assessed later in life, independent of confounding variables.</p>
Journal
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- Journal of Epidemiology
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Journal of Epidemiology 33 (2), 76-81, 2023-02-05
Japan Epidemiological Association