Apparent Life-Threatening Event in an Infant with SARS-CoV-2 Infection

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  • Sano Fumikazu
    Department of Pediatrics, University of Yamanashi, Japan
  • Yagasaki Hideaki
    Department of Pediatrics, University of Yamanashi, Japan
  • Kojika Satoru
    Department of Pediatrics, University of Yamanashi, Japan
  • Toda Takako
    Department of Pediatrics, University of Yamanashi, Japan
  • Kono Yosuke
    Department of Pediatrics, University of Yamanashi, Japan
  • Suzuki-Inoue Katsue
    Department of Clinical and Laboratory Medicine, University of Yamanashi, Japan
  • Sasaki Tomoyuki
    Department of Clinical and Laboratory Medicine, University of Yamanashi, Japan
  • Ogihara Shinji
    Department of Laboratory, University of Yamanashi, Japan
  • Matsuno Towa
    Department of Laboratory, University of Yamanashi, Japan
  • Inoue Osamu
    Division of Infection Control and Prevention, University of Yamanashi, Japan
  • Moriguchi Takeshi
    Department of Emergency and Critical Care Medicine, University of Yamanashi, Japan
  • Harii Norikazu
    Department of Community and Family Medicine, University of Yamanashi, Japan
  • Goto Junko
    Department of Emergency and Critical Care Medicine, University of Yamanashi, Japan
  • Shimizu Tatsuya
    Department of Radiology, University of Yamanashi, Japan
  • Inukai Takeshi
    Department of Pediatrics, University of Yamanashi, Japan

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Abstract

<p>The 2019 novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused a global outbreak of infection. In general, children with coronavirus disease-2019 have been reported to show milder respiratory symptoms than adult patients. Here, we have described a case of a SARS-CoV-2-infected infant who presented to our hospital with a severe episode of an apparent life-threatening event (ALTE). An 8-month-old, otherwise healthy female infant presented to our hospital because of a sudden cardiopulmonary arrest. Approximately 1 h before this episode, the patient showed no symptoms, except a worse humor than usual. On arrival at our hospital, the patient had severe acidosis, but there were no clear signs of inflammatory response. Chest computed tomography showed weak consolidations in the upper right lung and atelectasis in the lower left lung. No signs of congenital heart disease or cardiomyopathy were observed on echocardiography, and no significant arrhythmia was observed during the clinical course. However, SARS-CoV-2 RNA was detected by real-time reverse transcription polymerase chain reaction in tracheal aspirate and urine samples. Although the assessment of further similar cases is indispensable, this case suggests that SARS-CoV-2 infection may be an underlying factor in the pathophysiology of ALTE.</p>

Journal

  • Japanese Journal of Infectious Diseases

    Japanese Journal of Infectious Diseases 74 (3), 236-239, 2021-05-31

    National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee

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