Multisystem Inflammatory Syndrome in Children　― A New Syndrome Complicated With Acute Heart Failure Following Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection ―

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  • Uchida Momoko
    Department of Emergency and Critical Care Medicine, Shinshu University School of Medicine
  • Kashima Yuichiro
    Department of Emergency and Critical Care Medicine, Shinshu University School of Medicine
  • Mochizuki Katsunori
    Department of Emergency and Critical Care Medicine, Shinshu University School of Medicine
  • Sakamoto Hiroto
    Department of Emergency and Critical Care Medicine, Shinshu University School of Medicine
  • Mori Kotaro
    Department of Emergency and Critical Care Medicine, Shinshu University School of Medicine
  • Ebisawa Soichiro
    Department of Cardiology, Shinshu University School of Medicine
  • Takeshige Kanako
    Department of Emergency and Critical Care Medicine, Shinshu University School of Medicine
  • Nitta Kenichi
    Department of Emergency and Critical Care Medicine, Shinshu University School of Medicine
  • Kuwahara Koichiro
    Department of Cardiology, Shinshu University School of Medicine
  • Imamura Hiroshi
    Department of Emergency and Critical Care Medicine, Shinshu University School of Medicine

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Abstract

<p>Background:Multisystem inflammatory syndrome in children (MIS-C) is a rare syndrome temporally related to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). MIS-C shares similarities with Kawasaki disease, but left ventricular dysfunction is more common in MIS-C.</p><p>Methods and Results:This study reports the case of a 16-year-old Japanese male patient with MIS-C. Although the initial presentation was severe with circulatory and respiratory failure, the patient recovered completely. Endomyocardial biopsy showed active myocarditis with fibrosis. Immunoglobulin treatment was useful for recovery.</p><p>Conclusions:This is the first reported case of MIS-C in Japan. Cardiologists should be aware of MIS-C, a new disease, occurring during the global SARS-CoV-2 pandemic.</p>

Journal

  • Circulation Journal

    Circulation Journal 85 (6), 948-952, 2021-05-25

    The Japanese Circulation Society

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