Use of phosphorylated PAMAM and carboxyled PAMAM to induce dentin biomimetic remineralization and dentinal tubule occlusion
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- QIN Hejia
- Department of Endodontics, Stomatological Hospital, Guangxi Medical University
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- LONG Jindong
- Department of Endodontics, Stomatological Hospital, Guangxi Medical University
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- ZHOU Jun
- Department of Endodontics, Stomatological Hospital, Guangxi Medical University
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- WU Liuxian
- Department of Endodontics, Stomatological Hospital, Guangxi Medical University
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- XIE Fangfang
- Department of Endodontics, Stomatological Hospital, Guangxi Medical University
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抄録
<p>It is crucial to emphasize the biomineralization therapeutic method to repair etched dentin in clinic. Non-collagenous proteins (NCPs) play critical role in the biomineralization of dentine. In this paper, we synthesized the phosphate-terminated polyamidoamine dendrimer (PAMAM-PO3H2) by one-step modification successfully and examined by Fourier-transform infrared spectroscopy (FTIR) and 1H-nuclear Magnetic Resonance (1H-NMR) to characterize the structure of PAMAM-PO3H2. PAMAM-PO3H2 and carboxylterminated dendrimers (PAMAM-COOH) were applied as the dual biomimetic analogs of NCPs. Through the characterization of FT-IR, field emission scanning electron microscope (FE-SEM), transmission electron microscope (TEM), energy-dispersive X-ray spectroscopy (EDS) and X-ray diffraction (XRD), the surfaces of human dentin were covered with regenerated crystals and the dentinal tubules were occluded by PAMAM-PO3H2 and PAMAM-COOH. In summary, the combination of PAMAM-PO3H2 and PAMAM-COOH may be another feasible therapeutic method for the treatment of dentin caries and dentin hypersensitivity.</p>
収録刊行物
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- Dental Materials Journal
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Dental Materials Journal 40 (3), 800-807, 2021-05-25
一般社団法人 日本歯科理工学会