Effect of a chlorhexidine-encapsulated nanotube modified pit-and-fissure sealant on oral biofilm
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- FEITOSA Sabrina
- Department of Biomedical Sciences and Comprehensive Care, Indiana University School of Dentistry (IUSD)
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- CARREIRO Adriana F. P.
- Department of Dentistry, Federal University of Rio Grande do Norte
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- MARTINS Victor M.
- Department of Operative Dentistry and Dental Materials, Federal University of Uberlandia
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- PLATT Jeffrey A.
- Department of Biomedical Sciences and Comprehensive Care, Indiana University School of Dentistry (IUSD)
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- DUARTE Simone
- Department of Cariology, Operative Dentistry and Dental Public Health, Indiana University School of Dentistry (IUSD)
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<p>The purpose of this study was to characterize a chlorhexidine-encapsulated nanotube modified pit-and-fissure sealant for biofilm development prevention. HS (commercial control); HNT (HS+15wt%Halloysite®-clay-nanotube); CHX10% (HS+15wt% HNT-encapsulated with chlorhexidine 10%); and CHX20% (HS+15wt% HNT-encapsulated with CHX20%) were tested. Degree-of-conversion (DC%), Knoop hardness (KHN), and viscosity were analyzed. The ability of the sealant to wet the fissures was evaluated. Specimens were tested for zones of inhibition of microbial growth. S. mutans biofilm was tested by measuring recovered viability. Data were statistically analyzed (p<0.05). DC% was significantly higher for the HNT-CHX groups. For KHN, CHX10% presented a lower mean value than the other groups. Adding HNT resulted in higher viscosity values. The biofilm on CHX10% and CHX20% sealants presented remarkable CFU/mL reduction in comparison to the HS. The experimental material was able to reduce the biofilm development in S. mutans biofilm without compromising the sealant properties.</p>
収録刊行物
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- Dental Materials Journal
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Dental Materials Journal 40 (3), 758-765, 2021-05-25
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