Basic Verification of Cancer Cell Separation Characteristics in a Dielectrophoretic Device Using a Microcylindrical Electrodes
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- Miyamukai Hideo
- Tokyo Metropolitan University
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- Yagi Ippei
- Tokyo Metropolitan University
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- Uchida Satoshi
- Tokyo Metropolitan University
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- Takano Masayo
- AFI Corporation
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- Wakizaka Yoshikazu
- AFI Corporation
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- Enjoji Takaharu
- AFI Corporation
Bibliographic Information
- Other Title
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- 微小円柱電極を用いた誘電泳動デバイスにおけるがん細胞分離特性の基礎検証
- ビショウ エンチュウ デンキョク オ モチイタ ユウデン エイドウ デバイス ニ オケル ガン サイボウ ブンリ トクセイ ノ キソ ケンショウ
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Abstract
<p>Highly accurate isolation of circulating tumor cells (CTC) in the blood is essential for early detection of cancer. In particular, the dielectrophoretic device with a 3D structure can be expected to have separation accuracy, which cannot be obtained with conventional 2D shapes. In this study, an isolating leukemia-derived suspended Jurkat cell and fluorescent polystyrene particle, which are particles of uniform size, using a 3D microcylindrical electrodes are conducted. When the concentration of Jurkat cells was reduced to 1/100 of the concentration of polystyrene particles, Jurkat cells and polystyrene particles could be efficiently separated, and the collection efficiency at Outlet II, the outlet for the collection of target cells, was 100% and 2%, respectively. It was suggested that the proposed device may be able to separate cells of similar size with high accuracy.</p>
Journal
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- IEEJ Transactions on Sensors and Micromachines
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IEEJ Transactions on Sensors and Micromachines 141 (6), 179-185, 2021-06-01
The Institute of Electrical Engineers of Japan
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Details 詳細情報について
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- CRID
- 1390851165522881536
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- NII Article ID
- 130008046593
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- NII Book ID
- AN1052634X
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- ISSN
- 13475525
- 13418939
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- NDL BIB ID
- 031549166
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed