Effect of the Photocatalyst under Visible Light Irradiation in SARS-CoV-2 Stability on an Abiotic Surface
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- UEMA MASASHI
- Division of Biomedical Food Research, National Institute of Health Sciences
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- YONEMITSU KENZO
- Division of Biomedical Food Research, National Institute of Health Sciences
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- MOMOSE YOSHIKA
- Division of Biomedical Food Research, National Institute of Health Sciences
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- ISHII YOSHIKAZU
- Department of Microbiology and Infectious Diseases, Toho University School of Medicine
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- TATEDA KAZUHIRO
- Department of Microbiology and Infectious Diseases, Toho University School of Medicine
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- INOUE TAKAO
- Division of Molecular Target and Gene Therapy Products, National Institute of Health Sciences
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- ASAKURA HIROSHI
- Division of Biomedical Food Research, National Institute of Health Sciences
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Abstract
There is a worldwide attempt to develop prevention strategies against SARS-CoV-2 transmission. Here we examined the effectiveness of tungsten trioxide (WO3)-based visible light-responsive photocatalyst on the inactivation of SARS-CoV-2 under different temperatures and exposure durations. The viral titer on the photocatalyst-coated glass slides decreased from 5.93 ± 0.38 logTCID50 /mL to 3.05 ±. 25 logTCID50/mL after exposure to 3,000 lux of the visible light irradiation for 6h at 20℃. On the other hand, lighting without the photocatalyst, or the photocatalyst-coat without lighting retained viral stability. Immunoblotting and electron microscopic analyses showed the reduced amounts of spike protein on the viral surface after the photocatalyst treatment. Our data suggest a possible implication of the photocatalyst on the decontamination of SARS-CoV-2 in indoor environments, thereby preventing indirect viral spread.
Journal
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- Biocontrol Science
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Biocontrol Science 26 (2), 119-125, 2021
The Society for Antibacterial and Antifungal Agents, Japan