Effects of the ethanol extract of <i>Neopyropia yezoensis</i>, cultivated in the Seto Inland Sea (Setonaikai), on the viability of 10 human cancer cells including endocrine therapy-resistant breast cancer cells

• Takeda Shuso

  Laboratory of Molecular Life Sciences, Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University

• Hirao-Suzuki Masayo

  Laboratory of Xenobiotic Metabolism and Environmental Toxicology, Faculty of Pharmaceutical Sciences, Hiroshima International University (HIU)

• Yamagishi Yukimasa

  Department of Bio-Science, Faculty of Life Science and Biotechnology, Fukuyama University

• Sugihara Takahiro

  Laboratory of Molecular Life Sciences, Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University

• Kaneko Masataka

  Laboratory of Molecular Life Sciences, Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University

• Sakai Genki

  Laboratory of Molecular Life Sciences, Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University

• Nakamura Tetsuya

  Laboratory of Pharmacokinetics, Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University

• Hieda Yuhzo

  Commom Resources Center, Fukuyama University

• Takiguchi Masufumi

  Laboratory of Xenobiotic Metabolism and Environmental Toxicology, Faculty of Pharmaceutical Sciences, Hiroshima International University (HIU)

• Okada Masahiro

  Department of Pharmacy, Onomichi Municipal Hospital

• Sugihara Narumi

  Laboratory of Molecular Life Sciences, Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University

抄録

Here, we established an ethanol extraction method and obtained extracts of Neopyropia yezoensis cultivated in three different locations (extracts A-C) in the Seto Inland Sea (Setonaikai). The effects of the extracts on 10 human cancer cells derived from seven different organs were investigated. Extract A exerted the strongest anti-proliferative effects on all types of cancer cells, including an endocrine therapy-resistant aggressive breast cancer model, LTED cells. We analyzed the effects of the extracts on MCF-7 (parental cells for producing LTED cells)/LTED cells, along with four established anti-proliferative agents (etoposide, LY2835219, paclitaxel, and trichostatin A) with different action mechanisms. The inhibitory effects of extract A on both breast cancer cells were comparable with those of paclitaxel, although the other agents showed a preferable reduction in MCF-7 cell viability. We provide evidence of the involvement of component(s), especially those of extract A of N. yezoensis, which exerted anti-proliferative effects on cancer cells.

収録刊行物

• Fundamental Toxicological Sciences

  Fundamental Toxicological Sciences 8 (3), 75-80, 2021

  一般社団法人 日本毒性学会

キーワード

• <i>Neopyropia yezoensis</i>
• LTED cells
• Anti-proliferative activity
• Setonaikai

詳細情報

• CRID: 1390851407760665216
• NII論文ID: 130008055945
• DOI: 10.2131/fts.8.75
• ISSN: 2189115X
• Web Site: https://www.jstage.jst.go.jp/article/fts/8/3/8_75/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2022159284
• 本文言語コード: en
• データソース種別:
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  • Crossref
  • CiNii Articles
  • KAKEN
• 抄録ライセンスフラグ: 使用不可