Discovery of exosomal surface antigens for novel drug delivery systems

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  • Oyama Shota
    Chemistry of Functional Molecules, Graduate School of Biomedical Sciences, Nagasaki University
  • Yamayoshi Asako
    Chemistry of Functional Molecules, Graduate School of Biomedical Sciences, Nagasaki University

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Other Title
  • エクソソーム表面抗原に着目した新たな創薬モダリティの探索
  • エクソソーム ヒョウメン コウゲン ニ チャクモク シタ アラタ ナ ソウヤク モダリティ ノ タンサク

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Abstract

Exosomes are a type of extracellular vesicles （EVs） and have an in vivo molecular transport system. Nucleic acids and proteins （e.g., microRNAs, mRNAs） are encapsulated in the vesicle and secreted from cells, taken up by recipient cells, and then the cargo of exosomes are released intracellularly. Therefore, exosomes are highly expected as naturally occurring molecular carriers for drug delivery system （DDS）. We have recently developed a novel DDS “ExomiR-Tracker“ that can deliver anti-microRNA oligonucleotide to exosome-recipient cells associated with exosome by using arginized anti-exosome antibody. In this review, we introduce the characterization of exosomal surface antigens and summarize the technologies that utilize the proteins and lipids on the surface of exosome membranes.

Journal

  • Drug Delivery System

    Drug Delivery System 36 (2), 108-116, 2021-03-25

    THE JAPAN SOCIETY OF DRUG DELIVERY SYSTEM

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