Pyrrolactams from Marine Sponge Stylissa massa Collected from Myanmar and Their Anti-Vpr Activities

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  • Win Nwet Nwet
    Institute of Natural Medicine, University of Toyama
  • Kodama Takeshi
    Institute of Natural Medicine, University of Toyama
  • Aye Aung Aung
    Department of Marine Sciences, Myeik University
  • Lae Khine Zar Wynn
    Department of Chemistry, University of Yangon
  • Ngwe Hla
    Department of Chemistry, University of Yangon
  • Han Nang Mya
    Department of Marine Sciences, Myeik University
  • Abe Ikuro
    Graduate School of Pharmaceutical Sciences, The University of Tokyo Collaborative Research Institute for Innovative Microbiology, The University of Tokyo
  • Morita Hiroyuki
    Institute of Natural Medicine, University of Toyama

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  • Pyrrolactams from Marine Sponge <i>Stylissa massa</i> Collected from Myanmar and Their Anti-Vpr Activities

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<p>A new brominated pyrrolactam stylissaol A (1) together with four known analogues, 2-bromoaldisine, aldisine, spongiacidin D, and Z-hymenialdisine, were isolated from the EtOAc extract of marine sponge Stylissa massa collected in Myanmar. The absolute configuration at C-10 of 1 was determined as R by the electronic circular dichroism (ECD) data. Among the isolated compounds, 2-bromoaldisine showed anti-Viral Protein R (Vpr) activity against TREx-HeLa-Vpr cells with an effective dose of 10 µM and its potency was comparable to that of positive control damnacanthal.</p>

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