Lipid Dynamics due to Muscle Atrophy Induced by Immobilization
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- Kimura Keisuke
- Department of Marine Science and Resources, College of Bioresource Sciences, Nihon University
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- Morisasa Mizuki
- Department of Marine Science and Resources, College of Bioresource Sciences, Nihon University
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- Mizushige Takafumi
- School of Agriculture, Utsunomiya University
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- Karasawa Rikuo
- School of Agriculture, Utsunomiya University
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- Kanamaru Chinatsu
- School of Agriculture, Utsunomiya University
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- Kabuyama Yukihito
- School of Agriculture, Utsunomiya University
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- Hayasaka Takahiro
- Hokkaido University
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- Mori Tsukasa
- Department of Marine Science and Resources, College of Bioresource Sciences, Nihon University
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- Goto-Inoue Naoko
- Department of Marine Science and Resources, College of Bioresource Sciences, Nihon University
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Abstract
<p>Muscle atrophy refers to skeletal muscle loss and dysfunction that affects glucose and lipid metabolism. Moreover, muscle atrophy is manifested in cancer, diabetes, and obesity. In this study, we focused on lipid metabolism during muscle atrophy. We observed that the gastrocnemius muscle was associated with significant atrophy with 8 days of immobilization of hind limb joints and that muscle atrophy occurred regardless of the muscle fiber type. Further, we performed lipid analyses using thin layer chromatography, liquid chromatography-mass spectrometry, and mass spectrometry imaging. Total amounts of triacylglycerol, phosphatidylserine, and sphingomyelin were found to be increased in the immobilized muscle. Additionally, we found that specific molecular species of phosphatidylserine, phosphatidylcholine, and sphingomyelin were increased by immobilization. Furthermore, the expression of adipose triglyceride lipase and the activity of cyclooxygenase-2 were significantly reduced by atrophy. From these results, it was revealed that lipid accumulation and metabolic changes in specific fatty acids occur during disuse muscle atrophy. The present study holds implications in validating preventive treatment strategies for muscle atrophy.</p>
Journal
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- Journal of Oleo Science
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Journal of Oleo Science 70 (7), 937-946, 2021
Japan Oil Chemists' Society
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Keywords
Details 詳細情報について
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- CRID
- 1390288547259985408
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- NII Article ID
- 130008060027
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- NII Book ID
- AA11503337
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- ISSN
- 13473352
- 13458957
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- NDL BIB ID
- 031529037
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- PubMed
- 34193670
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed