STAP-2 Adaptor Protein Regulates Multiple Steps of Immune and Inflammatory Responses
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- Matsuda Tadashi
- Department of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University
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- Oritani Kenji
- Department of Hematology, International University of Health and Welfare
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Abstract
<p>Signal-transducing adaptor protein (STAP)-2 is an adaptor molecule involved in regulation of several intracellular signaling events in immune cells. STAP-2 contains a pleckstrin homology domain at the N-terminus, an src homology domain in the central portion and a proline-rich region at the C-terminus. STAP-2 also has a YXXQ motif, which is a potential signal transducer and activator of transcription (STAT)3-binding site. STAP-2 influences the STAT3 and STAT5 activity, integrin-mediated T cell adhesion, chemokine-induced T cell migration, Fas-mediated T cell apoptosis, Toll-like receptor-mediated macrophage functions, macrophage colony-stimulating factor-induced macrophage activation, and the high-affinity immunoglobulin E receptor-mediated mast cell activation. This article reviews the current understanding of roles of the STAP-2 during immune and/or inflammatory responses, and discusses possible therapeutic applications of targeting STAP-2 proteins in immune-related disorders.</p>
Journal
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- Biological and Pharmaceutical Bulletin
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Biological and Pharmaceutical Bulletin 44 (7), 895-901, 2021-07-01
The Pharmaceutical Society of Japan
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Keywords
Details 詳細情報について
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- CRID
- 1390851497213549568
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- NII Article ID
- 130008060362
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- NII Book ID
- AA10885497
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- ISSN
- 13475215
- 09186158
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- HANDLE
- 2115/87607
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- NDL BIB ID
- 031534881
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- PubMed
- 34193686
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- Text Lang
- en
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- Data Source
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- JaLC
- IRDB
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed