Mechanical Bone Strength in Immobilized Osteopenia：An <i>In Vivo</i> Study

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  • Koseki Hironobu
    Department of Health Sciences, Nagasaki University Graduate School of Biomedical Sciences Division of Physical Therapy, Nagasaki University School of Health Sciences
  • Honda Yuichiro
    Division of Physical Therapy, Nagasaki University School of Health Sciences Department of Locomotive Rehabilitation Science, Nagasaki University Graduate School of Biomedical Sciences
  • Sunagawa Shinya
    Department of Health Sciences, Nagasaki University Graduate School of Biomedical Sciences
  • Matsumura Umi
    Department of Health Sciences, Nagasaki University Graduate School of Biomedical Sciences
  • Sakamoto Junya
    Division of Physical Therapy, Nagasaki University School of Health Sciences Department of Locomotive Rehabilitation Science, Nagasaki University Graduate School of Biomedical Sciences
  • Okita Minoru
    Division of Physical Therapy, Nagasaki University School of Health Sciences Department of Locomotive Rehabilitation Science, Nagasaki University Graduate School of Biomedical Sciences

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Other Title
  • 不動性骨萎縮による機械的骨強度
  • フドウセイ ホネ イシュク ニ ヨル キカイテキ ホネ キョウド

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Abstract

<p>Objective：This study aimed to evaluate the mechanical strength of immobilized osteopenia using a fixed limb rat model.</p><p>Methods：Eight-week-old specific-pathogen-free male Wistar rats were divided into two groups, a control group (n＝32) and an immobilized group (n＝32). The hind limbs of the immobilized group were fixed using an orthopedic cast, and the fixation periods were set for 1, 4, 8, and 12 weeks. Feeding and weight-bearing were permitted. After each fixation period, the length of the right femoral bone was measured, and three-point bending at the midshaft and uniaxial compression test at the distal metaphysis were performed with a universal material testing apparatus. The maximum force and breaking force in the bending test and ultimate load in the compression test were statistically analyzed.</p><p>Results：The values of the maximum force and breaking force in the immobilized group were significantly lower than those in the control group at 4, 8, and 12 weeks (p＜0.05). The ultimate load of the distal metaphysis in the immobilized group decreased from 1 week after fixation, and the gap with the control group widened as the fixation period extended.</p><p>Conclusion：The results of this study indicate that bone weakness caused by immobilized osteopenia arises after 1 week in the metaphysis and after 4 weeks in the midshaft.</p>

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