Higher Non-fasting Serum Triglyceride Preceding the Carotid Stenosis Progression
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- MIURA Yoichi
- Department of Neurosurgery, Mie University Graduate School of Medicine
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- SUZUKI Yume
- Department of Neurosurgery, Mie University Graduate School of Medicine
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- KANAMARU Hideki
- Department of Neurosurgery, Mie University Graduate School of Medicine
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- SHIBA Masato
- Department of Neurosurgery, Mie University Graduate School of Medicine
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- YASUDA Ryuta
- Department of Neurosurgery, Mie University Graduate School of Medicine
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- TOMA Naoki
- Department of Neurosurgery, Mie University Graduate School of Medicine
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- SUZUKI Hidenori
- Department of Neurosurgery, Mie University Graduate School of Medicine
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<p>The present study was conducted to investigate whether non-fasting serum triglyceride (TG) levels can be used to assess a risk for the progression of carotid artery stenosis. This was a single-center retrospective study. Consecutive 96 patients with ≥50% stenosis of at least unilateral cervical internal carotid artery and normal fasting serum low-density lipoprotein cholesterol (LDL-C) levels of ≤140 mg/dL were followed up for at least 1 year (mean, 3.1 years), and clinical variables were compared between patients with and without carotid stenosis progression (≥10% increases in the degree on ultrasonography). Carotid stenosis progression was shown in 21 patients, associated with less frequent treatment with calcium channel blockers (CCBs), higher non-fasting TG and glucose levels. In carotid artery-based analyses including <50% stenosis side, stenosis progression was shown in 23 of 121 arteries except for those with complete occlusion and less than 1-year follow-up period because of carotid artery stenting (CAS) or carotid endarterectomy (CEA). Stenosis progression was more frequently observed in symptomatic and/or radiation-induced lesions, and was also accompanied with less frequent treatment with CCBs, higher non-fasting TG and glucose levels in carotid artery-based analyses. The receiver operating characteristic (ROC) curve analyses revealed that a cutoff value of non-fasting TG to discriminate carotid stenosis progression was 169.5 mg/dL for carotid arteries with the baseline stenosis of <50%, and 154.5mg/dL for those of ≥50%. Non-fasting TG level was an independent risk factor of carotid stenosis progression, and more strict control of non-fasting TG may be necessary for higher degree of carotid artery stenosis.</p>
収録刊行物
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- Neurologia medico-chirurgica
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Neurologia medico-chirurgica 61 (7), 422-432, 2021
一般社団法人 日本脳神経外科学会