Angiosarcoma of the oropharynx

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  • Ishihara Hiromasa
    Department of Otolaryngology, Gifu University school of medicine Department of Otolaryngology, Ichinomiya Nishi Hospital
  • Kuze Bunya
    Department of Otolaryngology, Gifu University school of medicine
  • Ohhashi Toshimitsu
    Department of Otolaryngology, Gifu University school of medicine
  • Nishihori Takesumi
    Department of Otolaryngology, Gifu University school of medicine
  • Aoki Mitsuhiro
    Department of Otolaryngology, Gifu University school of medicine

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  • 中咽頭血管肉腫の1例

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Abstract

Angiosarcoma is a rare soft tissue malignancy that accounts for 2％ of soft tissue sarcomas. Most cases of angiosarcoma in the head and neck originate in the skin of the head; those originating in the oropharynx are extremely rare. We experienced a case of oropharyngeal angiosarcoma with multiple distant metastases from the first visit.<br>The prognosis for angiosarcoma is very poor. Especially for those with distant metastases, the median survival time was reported to be about 3 months, and there is no clear treatment policy with evidence.<br>In the present case, chemotherapy with paclitaxel resolved the oropharyngeal lesion. Although the distant lesion had also shrunk, a new distant lesion appeared and increased, so we changed the chemotherapy to pazopanib. Paclitaxel had a progression-free survival （PFS） of 6 months and an overall survival （OS） of 17 months. A case report is made, with a review of the literature.

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