Roles of Glypican and Heparan Sulfate at the Synapses
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- Kamimura Keisuke
- Department of Brain and Neurosciences, Tokyo Metropolitan Institute of Medical Science
Bibliographic Information
- Other Title
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- シナプスにおけるグリピカンとへパラン硫酸の役割
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Abstract
<p>Heparan sulfate proteoglycans (HSPGs) interact with various proteins through the HS chains and regulate many biological processes, and mutations in HSPG genes cause a variety of diseases. Recent studies in vertebrates and invertebrates have highlighted the importance of HSPGs glypicans in the development and function of synapses. Glypicans interact with various synapse-organizing proteins, such as LRRTMs and LAR family RPTPs, regulating synapse formation. Well-known presynaptic organizers, neurexins, function as HSPGs and bind to several proteins in common with glypicans through HS chains. Furthermore, glypicans regulate the postsynaptic levels of ionotropic glutamate receptors, controlling synaptic transmission. Mutations in glypican genes in model organisms affect synaptic development and function and cause abnormal behaviors. Recent human genetic studies also revealed associations of glypicans and HS with autism spectrum disorder. In this minireview, I describe the roles of glypicans and HS in synapse formation and neural plasticity as well as involvement in neurological diseases.</p>
Journal
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- Trends in Glycoscience and Glycotechnology
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Trends in Glycoscience and Glycotechnology 33 (194), J85-J90, 2021-07-25
FCCA(Forum: Carbohydrates Coming of Age)
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Details 詳細情報について
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- CRID
- 1390570319883552512
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- NII Article ID
- 130008068233
- 130008068232
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- NII Book ID
- AA10995236
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- ISSN
- 18832113
- 09157352
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- NDL BIB ID
- 032108506
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed