Human tissue generation from hiPSC-derived organoids utilizing microgravity: Space experiments open a new door for regenerative medicine.

DOI
  • Tadokoro Tomomi
    Department of Regenerative Medicine, Yokohama City University Graduate School of Medicine Division of Regenerative Medicine, Center for Stem Cell Biology and Regenerative Medicine, Institute of Medical Science, University of Tokyo
  • Taniguchi Hideki
    Department of Regenerative Medicine, Yokohama City University Graduate School of Medicine Division of Regenerative Medicine, Center for Stem Cell Biology and Regenerative Medicine, Institute of Medical Science, University of Tokyo

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Other Title
  • 微小重力を活用しヒト臓器を創る　～宇宙実験が開く新たな再生医学の扉～

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Abstract

<p>Organ transplantation is the only definitive treatment for patients suffering end-stage organ failure. However, donor-organ shortage is a severe problem worldwide, and therefore, the development of alternative treatments is urgently needed. The emergence of human induced pluripotent stem cells (hiPSC) is a game-changer for regenerative medicine as it can supply enough cells required for treatment; clinical trials are now conducted in Japan. To generate human tissues from hiPSC for future regenerative medicine, organoid technology offers one of the promising strategies. In this review, we describe the advances in organoid research which we are promoting by utilizing microgravity environment.</p>

Journal

  • Organ Biology

    Organ Biology 28 (2), 147-153, 2021

    The Japan Society for Organ Preservation and Biology

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