The Monocyte to High-Density Lipoprotein Cholesterol Ratio Is Associated with Left Ventricular Diastolic Function in Patients with No Significant Perfusion Abnormality
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- Fukuda Yukihiro
- Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences
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- Nitta Kazuhiro
- Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences
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- Kurisu Satoshi
- Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences
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- Watanabe Noriaki
- Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences
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- Ikenaga Hiroki
- Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences
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- Ishibashi Ken
- Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences
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- Nakano Yukiko
- Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences
書誌事項
- タイトル別名
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- Assessment by Myocardial Perfusion Single-Photon Emission Computed Tomography
抄録
<p>The monocyte to high-density lipoprotein cholesterol (HDL-C) ratio has been considered to be a prognostic marker. Whether this ratio is associated with left ventricular (LV) diastolic function remains undetermined. We tested the hypothesis that the monocyte to HDL-C ratio is associated with LV diastolic parameters derived from gated myocardial perfusion single-photon emission computed tomography (SPECT) in patients with no significant perfusion abnormality.</p><p>The study population included 196 patients with no significant perfusion abnormalities and preserved ejection fraction. The peak filling rate (PFR) and one-third mean filling rate (1/3 MFR) were obtained as LV diastolic parameters using gated SPECT. Monocyte counts and plasma HDL-C levels were also examined.</p><p>Significant associations were observed between the monocyte to HDL-C ratio and PFR (r = −0.20; P = 0.005) and 1/3 MFR (r = −0.19; P = 0.009). Multivariate linear regression analysis was performed to determine factors associated with LV diastolic parameters. Age (β = −0.27; P < 0.001), LV end-diastolic volume (β = −0.19; P = 0.034), and monocyte to HDL-C ratio (β = −0.15; P = 0.027) were determined to be significantly associated with PFR. Moreover, age (β = −0.13; P = 0.007), LV mass index (β = −0.18; P = 0.037), and the monocyte to HDL-C ratio (β = −0.13; P = 0.045) were significantly associated with 1/3 MFR.</p><p>These results demonstrated that the monocyte to HDL-C ratio is associated with LV diastolic function, as derived from gated SPECT in patients with no significant perfusion abnormality.</p>
収録刊行物
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- International Heart Journal
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International Heart Journal 62 (4), 866-871, 2021-07-30
一般社団法人 インターナショナル・ハート・ジャーナル刊行会
