Effect of the Sodium-Glucose Cotransporter 2 Inhibitor Canagliflozin for Heart Failure With Preserved Ejection Fraction in Patients With Type 2 Diabetes
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- Ueda Tomoya
- Cardiovascular Medicine, Nara Medical University
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- Kasama Shu
- Institute for Clinical and Translational Science, Nara Medical University Hospital
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- Yamamoto Masahiro
- Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University
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- Nakano Tomoya
- Department of Cardiovascular Medicine, Yamato Takada Municipal Hospital
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- Ueshima Kazuhiro
- Department of Cardiovascular Medicine, Yamato Takada Municipal Hospital
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- Morikawa Yoshinobu
- Department of Cardiovascular Medicine, Minami-Nara General Medical Center
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- Kawata Hiroyuki
- Department of Cardiovascular Medicine, Nara Prefecture General Medical Center
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- Yoshihisa Akiomi
- Department of Cardiovascular Medicine, Fukushima Medical University
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- Nakayama Masafumi
- Nakayama Cardiovascular Clinic
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- Komatsu Sei
- Cardiovascular Center, Osaka Gyoumeikan Hospital
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- Soeda Tsunenari
- Cardiovascular Medicine, Nara Medical University
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- Watanabe Makoto
- Cardiovascular Medicine, Nara Medical University
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- Kawakami Rika
- Cardiovascular Medicine, Nara Medical University
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- Okada Yasushi
- Ikuyaku, Integrated Value Development, Mitsubishi Tanabe Pharma Corporation
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- Tanaka Hiroyuki
- Ikuyaku, Integrated Value Development, Mitsubishi Tanabe Pharma Corporation
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- Susuta Yutaka
- Ikuyaku, Integrated Value Development, Mitsubishi Tanabe Pharma Corporation
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- Kasahara Masato
- Institute for Clinical and Translational Science, Nara Medical University Hospital
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- Tsujita Kenichi
- Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University
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- Takeishi Yasuchika
- Department of Cardiovascular Medicine, Fukushima Medical University
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- Saito Yoshihiko
- Cardiovascular Medicine, Nara Medical University
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<p>Background:The efficacy of sodium-glucose cotransporter 2 (SGLT2) inhibitors in elderly patients with heart failure with preserved ejection fraction (HFpEF) remains unclear.</p><p>Methods and Results:In a multicenter, controlled trial, the CANONICAL study, we enrolled 82 HFpEF (left ventricular ejection fraction [LVEF] ≥50%) patients with type 2 diabetes (T2D) aged ≥65 years, with plasma B-type natriuretic peptide (BNP) ≥100 pg/mL or plasma N-terminal pro BNP (NT-proBNP) ≥400 pg/mL or history of HF. Patients were randomly assigned to 2 groups and were administered either the SGLT2 inhibitor canagliflozin (100 mg/day) for 24 weeks or standard therapy. The primary endpoints were changes in body weight (BW) and BNP concentrations. Mean (±SD) patient age, body mass index, and LVEF were 75.7±6.5 years, 25.0±3.6 kg/m2and 61.5±7.6%, respectively. At 24 weeks, BW was significantly lower in the canagliflozin than standard therapy group. The extent of BNP reductions at 4 weeks was significantly greater in the canagliflozin than standard therapy group (P<0.05), but at 24 weeks there was no significant difference between the 2 groups.</p><p>Conclusions:In this study, canagliflozin treatment reduced BW, but did not significantly reduce plasma BNP concentrations compared with standard therapy after 24 weeks treatment in T2D patients with HFpEF. Further large-scale randomized studies are needed to conclude the beneficial effects of canagliflozin in T2D patients with HFpEF.</p>
収録刊行物
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- Circulation Reports
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Circulation Reports 3 (8), 440-448, 2021-08-10
一般社団法人 日本循環器学会
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- CRID
- 1390570465069315200
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- NII論文ID
- 130008072739
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- ISSN
- 24340790
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- en
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