Histological observation on the initial stage of vascular invasion into the secondary ossification of murine femoral epiphyseal cartilage
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- HASHIMOTO Keiji
- Developmental Biology of Hard Tissue, Graduate School of Dental Medicine and Faculty of Dental Medicine, Hokkaido University Dental Anesthesiology, Graduate School of Dental Medicine and Faculty of Dental Medicine, Hokkaido University
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- HASEGAWA Tomoka
- Developmental Biology of Hard Tissue, Graduate School of Dental Medicine and Faculty of Dental Medicine, Hokkaido University
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- YAMAMOTO Tomomaya
- Developmental Biology of Hard Tissue, Graduate School of Dental Medicine and Faculty of Dental Medicine, Hokkaido University Northern Army Medical Unit, Camp Makomanai, Japan Ground Self-Defense Forces
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- HONGO Hiromi
- Developmental Biology of Hard Tissue, Graduate School of Dental Medicine and Faculty of Dental Medicine, Hokkaido University
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- IMIN Y
- Central Research Institute, Faculty of Medicine and Graduate School of Medicine, Hokkaido University
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- ABE Miki
- Developmental Biology of Hard Tissue, Graduate School of Dental Medicine and Faculty of Dental Medicine, Hokkaido University
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- NASOORI Alireza
- Developmental Biology of Hard Tissue, Graduate School of Dental Medicine and Faculty of Dental Medicine, Hokkaido University
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- NAKANISHI Ko
- Biomaterials and Bioengineering, Graduate School of Dental Medicine and Faculty of Dental Medicine, Hokkaido University Orthodontics, Graduate School of Dental Medicine and Faculty of Dental Medicine, Hokkaido University
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- MARUOKA Haruhi
- Developmental Biology of Hard Tissue, Graduate School of Dental Medicine and Faculty of Dental Medicine, Hokkaido University Orthodontics, Graduate School of Dental Medicine and Faculty of Dental Medicine, Hokkaido University
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- MORIMOTO Yasuhito
- Developmental Biology of Hard Tissue, Graduate School of Dental Medicine and Faculty of Dental Medicine, Hokkaido University Periodontology and Endodontology, Graduate School of Dental Medicine and Faculty of Dental Medicine, Hokkaido University
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- KUBOTA Keisuke
- Developmental Biology of Hard Tissue, Graduate School of Dental Medicine and Faculty of Dental Medicine, Hokkaido University Oral Functional Prosthodontics, Graduate School of Dental Medicine and Faculty of Dental Medicine, Hokkaido University
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- SHIMIZU Tomohiro
- Department of Orthopaedic Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University
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- HARAGUCHI Mai
- Developmental Biology of Hard Tissue, Graduate School of Dental Medicine and Faculty of Dental Medicine, Hokkaido University
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- TAKAHATA Masahiko
- Department of Orthopaedic Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University
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- IWASAKI Norimasa
- Department of Orthopaedic Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University
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- LI Minqi
- Shandong Provincial Key Laboratory of Oral Biomedicine, The School of Stomatology, Shandong University
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- FUJISAWA Toshiaki
- Dental Anesthesiology, Graduate School of Dental Medicine and Faculty of Dental Medicine, Hokkaido University
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- AMIZUKA Norio
- Developmental Biology of Hard Tissue, Graduate School of Dental Medicine and Faculty of Dental Medicine, Hokkaido University
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Abstract
<p>It remains unknown whether the histology of vascular invasion during secondary ossification of epiphyseal cartilage is the same as that seen in primary ossification; we examined the initial processes of vascular invasion of secondary ossification in the murine femora. Many endomucin-immunoreactive blood vessels gathered at the central region of the articular surface, and buds of soft tissue, including glomerular loops of endomucin-immunoreactive blood vessels and TNALPase- immunopositive osteoblastic cells accompanied by TRAP-positive osteoclasts, had begun to invade the epiphyseal cartilage. The invading soft tissues formed cartilage canals displaying MMP9 immunoreactivity in the tip region, and cartilaginous collagen fibrils were not visible in the vicinity of the vascular wall of the blood vessels. Thus, the histological profile marked by invading glomerular vasculature and the erosion of the cartilage matrix near the vascular walls during secondary ossification differs from that seen during primary ossification.</p>
Journal
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- Biomedical Research
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Biomedical Research 42 (4), 139-151, 2021-08-12
Biomedical Research Press