High Levels of Dietary Lard or Sucrose May Aggravate Lysosomal Renal Injury in Non-Obese, Streptozotocin-Injected CD-1 Mice Provided Isocaloric Diets

DOI Web Site Web Site 参考文献37件
  • YOSHIMURA Aya
    Education and Research Center of Animal Models for Human Diseases, Fujita Health University
  • YAMAGUCHI Tamio
    Department of Clinical Nutrition, Faculty of Health Science, Suzuka University of Medical Science
  • KUGITA Masanori
    Education and Research Center of Animal Models for Human Diseases, Fujita Health University
  • KUMAMOTO Kanako
    Education and Research Center of Animal Models for Human Diseases, Fujita Health University
  • SHIOGAMA Kazuya
    Division of Morphology and Cell Function, Faculty of Medical Technology, School of Health Sciences, Fujita Health University
  • OGITSU Naomichi
    Department of Clinical Nutrition, Faculty of Health Science, Suzuka University of Medical Science
  • YONEDA Misao
    Department of Clinical Nutrition, Faculty of Health Science, Suzuka University of Medical Science
  • MIURA Toshihiro
    Department of Clinical Nutrition, Faculty of Health Science, Suzuka University of Medical Science
  • NAGAMURA Yoichi
    Department of Clinical Nutrition, Faculty of Health Science, Suzuka University of Medical Science
  • NAGAO Shizuko
    Education and Research Center of Animal Models for Human Diseases, Fujita Health University

この論文をさがす

抄録

<p>Daily fat and sugar intake has increased in Japan, while total energy intake has decreased. However, the number of type 2 diabetes mellitus patients has increased, and this often causes renal injury characterized by autophagic vacuoles. Although many studies with comparisons of high fat or sugar versus a normal macronutrient balanced diet have been reported, there are few studies that equalized calorie intake and body weights. In the current study, AIN93M diets (CONT group) with matching energy content with lard derived high saturated fat (LARD group), soybean oil derived unsaturated fat (SOY OIL group) and sucrose (SUCROSE group) were provided to compare their effects on renal morphology in streptozotocin-injected CD-1 mice without causing obesity. The number of renal tubular vacuoles was higher in SUCROSE and slightly higher in LARD compared with CONT mice, and was higher in LARD and SUCROSE compared with SOY OIL mice. Most of those vacuoles were LAMP1-positive, a marker of lysosomal autophagy. These results suggest that despite identical energy contents, diets with high sucrose or saturated fat compared to unsaturated fat may aggravate lysosomal renal injury in a non-obese, streptozotocin-induced model of diabetes mellitus.</p>

収録刊行物

参考文献 (37)*注記

もっと見る

関連プロジェクト

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ