A Study on Fourteen Cases of Sinonasal Mucosal Malignant Melanoma

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  • 鼻副鼻腔粘膜悪性黒色腫14例の検討
  • ハナ フクビコウ ネンマク アクセイ コクショク シュ 14レイ ノ ケントウ

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Abstract

<p>We reviewed the clinical data of 14 patients with mucosal malignant melanoma of the nasal/paranasal cavity from among 78 patients diagnosed as having malignant nasal/paranasal cavity tumors at our hospital between 2008 and 2018. There were 4 men and 10 women, aged 49–85 years (median: 69.0). The clinical TNM classification according to the 8th American Joint Committee on Cancer and the International Union Against Cancer Control (AJCC/UICC) was as follows: T3, 9 cases; T4a, 4 cases; T4b, 1 case; N0, 13 cases; N1, 1 case; stage III, 9 cases; stage IVA, 4 cases; stage IVc, 1 case. The overall 2-year, 3-year and 5-year survival rates (Kaplan-Meier method) were 50.0%, 42.9%, and 42.9%, respectively. The 2-year, 3-year and 5-year local control rates (Kaplan-Meier method) were 42.9%, 42.9%, 32.1%, respectively. Examination of the prognostic factors by univariate analysis showed that the prognosis was significantly poor in patients with cT4 or higher, with tumors in the sinuses, and with distant metastases. Examination of the surgical cases showed that distant metastases developed in 58.3% of cases even after complete resection by surgery. Control of distant metastasis is considered as being a problem that needs to be resolved in order to improve the treatment results of mucosal malignant melanoma of the nasal/paranasal cavity.</p>

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