Shanpanootols G and H, Diterpenoids from the Rhizomes of Kaempferia pulchra Collected in Myanmar and Their Vpr Inhibitory Activities

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  • Win Nwet Nwet
    Institute of Natural Medicine, University of Toyama
  • Kodama Takeshi
    Institute of Natural Medicine, University of Toyama
  • Htoo Zin Paing
    Institute of Natural Medicine, University of Toyama
  • Hnin Saw Yu Yu
    Institute of Natural Medicine, University of Toyama
  • Ngwe Hla
    Department of Chemistry, University of Yangon
  • Abe Ikuro
    Graduate School of Pharmaceutical Sciences, The University of Tokyo Collaborative Research Institute for Innovative Microbiology, The University of Tokyo
  • Morita Hiroyuki
    Institute of Natural Medicine, University of Toyama

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  • Shanpanootols G and H, Diterpenoids from the Rhizomes of <i>Kaempferia pulchra</i> Collected in Myanmar and Their Vpr Inhibitory Activities

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<p>Two new trihydroxy derivative of Δ8(14),15-isopimarane diterpenoids, shanpanootols G (1) and H (2), along with three known analogues were isolated from the ethyl acetate-soluble extract of Kaempferia pulchra rhizomes collected in Shan State of Myanmar. The structures of these compounds including their absolute configurations were elucidated by the combination of one dimensional (1D) and 2D-NMR spectroscopic methods, high resolution mass spectrometric technique, and the experimental and the calculated electronic circular dichroism (ECD) data. The isopimarane diterpenoids (1–5) were tested for their Viral protein R (Vpr) inhibitory activities against TREx-HeLa-Vpr cells. Shanpanootol H (2) and (1R,2S,5S,9R,10S,13R)-1,2-dihydroxypimara-8(14),15-dien-7-one (4) exhibited anti-Vpr activities at the 5 µM treated dose.</p>

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