The cytotoxicity of cyclophosphamide is enhanced in combination with monascus pigment
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- Kurokawa Hiromi
- Algae Biomass Research and Development, University of Tsukuba
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- Taninaka Atsushi
- Graduate School of Comprehensive Human Sciences, University of Tsukuba
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- Shigekawa Hidemi
- Graduate School of Comprehensive Human Sciences, University of Tsukuba
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- Matsui Hirofumi
- Algae Biomass Research and Development, University of Tsukuba Faculty of Medicine, University of Tsukuba
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Abstract
<p>Monascus pigment is derived from red-mold rice fermented by monascus purpureus and utilized as a natural coloring agent and natural food additive in East Asia. Monascus pigment works as a radical scavenger. Some antioxidant combine cancer chemotherapy to protect normal tissue because chemotherapy induce side effect for normal tissue. This combination therapy can attenuate the cytotoxicity of anticancer drugs by antioxidants effects. However, the effect of this combination therapy for cancer cells dose not investigate enough. In this study, we investigated the combination effect of antioxidants and anticancer drugs. We selected an antioxidant as monascus pigment and following four anticancer drugs: doxorubicin, tamoxifen, paclitaxicel, and cyclophosphamide. Combination treatment with monascus pigment and cyclophosphamide enhanced the cytotoxicity of cyclophosphamide. Moreover, this combination treatment accelerated apoptosis. The spot on TLC assay board of the monascus pigment and cyclophosphamide mixture is different from the spot of monascus pigment alone and cyclophosphamide alone. The interaction between monascus pigment and cyclophosphamide can produce some cytotoxicity compounds or accelerate intracellular cyclophosphamide accumulation. Hence, we concluded that the interaction of both cyclophosphamide and monascus pigment involved enhancement of cyclophosphamide cytotoxicity.</p>
Journal
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- Journal of Clinical Biochemistry and Nutrition
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Journal of Clinical Biochemistry and Nutrition 69 (2), 131-136, 2021
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Details 詳細情報について
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- CRID
- 1390289232190550016
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- NII Article ID
- 130008082417
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- ISSN
- 18805086
- 09120009
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- Text Lang
- en
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed