Impact of clinical characteristics of colonic diverticular bleeding in extremely elderly patients treated with direct oral anti-coagulant drugs: a retrospective multi-center study
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- Kirita Kumiko
- Division of Gastroenterology, Nippon Medical School Division of Gastroenterology, Tama-Hokubu Medical Center
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- Kodaka Yasuhiro
- Division of Gastroenterology, Nippon Medical School Division of Gastroenterology, Nippon Medical School Musashikosugi Hospital
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- Shibata Yoshiaki
- Division of Gastroenterology, Tama-Hokubu Medical Center
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- Ueki Nobue
- Division of Gastroenterology, Nippon Medical School Division of Gastroenterology, Nippon Medical School Musashikosugi Hospital
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- Agawa Shuhei
- Division of Gastroenterology, Nippon Medical School Division of Gastroenterology, Nippon Medical School Musashikosugi Hospital
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- Yamawaki Hiroshi
- Division of Gastroenterology, Nippon Medical School Division of Gastroenterology, Nippon Medical School Musashikosugi Hospital
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- Niikura Ryota
- Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo
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- Yamamichi Nobutake
- Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo
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- Izumi Kentaro
- Department of Gastroenterology, Juntendo University School of Medicine
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- Hojo Mariko
- Department of Gastroenterology, Juntendo University School of Medicine
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- Maruyama Kyohei
- Division of Gastroenterology, Department of Medicine, Teikyo University School of Medicine
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- Yamamoto Takatsugu
- Division of Gastroenterology, Department of Medicine, Teikyo University School of Medicine
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- Gudis Katya
- Division of Gastroenterology, Nippon Medical School
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- Watanabe Masanori
- Division of Surgery, Nippon Medical School Musashikosugi Hospital
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- Kaise Mitsuru
- Division of Gastroenterology, Nippon Medical School
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- Iwakiri Katsuhiko
- Division of Gastroenterology, Nippon Medical School
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- Futagami Seiji
- Division of Gastroenterology, Nippon Medical School Division of Gastroenterology, Nippon Medical School Musashikosugi Hospital
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<p>Since there were no available data about colonic diverticular bleeding in extremely elderly patients (>80 years old) treated with direct oral anticoagulants (DOACs), we tried to determine clinical characteristics in those with colonic diverticular bleeding taking DOACs and to compare clinical outcomes of those in DOAC-treated to those in warfarin-treated . We enrolled DOAC-treated (n = 20) and warfarin-treated (n = 23) extremely elderly patients with diverticular bleeding diagnosed by colonoscopy. We performed a retrospective review of patients’ medical charts and endoscopic findings. We classified colonic diverticular bleeding based on endoscopic features due to modified previous study following three groups, type A (active bleeding), type B (non-active bleeding) and type C (bleeding suspected). Clinical outcomes such as number of recurrent bleeding, thrombotic events and mortality were estimated. There were no differences in endoscopical features and clinical characteristics between patients treated with DOAC and warfarin therapy. However, the number of recurrent bleeding, frequency of required blood transfusions and units of blood transfusion in warfarin-treated patients were significantly higher (p<0.05) compared to those in DOAC-treated groups. In addition, mortality and thrombotic events did not differ between DOAC- and warfarin-treated patients. Clinical outcomes suggest that DOACs can be recommended for extremely elderly patients with colonic diverticular disease.</p>
収録刊行物
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- Ｊｏｕｒｎａｌ ｏｆ Ｃｌｉｎｉｃａｌ Ｂｉｏｃｈｅｍｉｓｔｒｙ ａｎｄ Ｎｕｔｒｉｔｉｏｎ
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Ｊｏｕｒｎａｌ ｏｆ Ｃｌｉｎｉｃａｌ Ｂｉｏｃｈｅｍｉｓｔｒｙ ａｎｄ Ｎｕｔｒｉｔｉｏｎ 69 (2), 222-228, 2021
一般社団法人 日本酸化ストレス学会
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詳細情報 詳細情報について
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- CRID
- 1390289232191565440
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- NII論文ID
- 130008082419
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- ISSN
- 18805086
- 09120009
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可
