Cystine supplementation sustains plasma mercaptalbumin levels in rats fed low-protein diets more effectively than methionine
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- Yano Yukimi
- Department of Nutrition Science, Graduate School of Life and Environmental Sciences, Kyoto Prefectural University
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- Maeda Chihiro
- Department of Nutrition Science, Graduate School of Life and Environmental Sciences, Kyoto Prefectural University
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- Kaneko Ichiro
- Department of Applied Nutrition, Tokushima University Graduate School of Biomedical Sciences
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- Kobayashi Yukiko
- Department of Nutrition Science, Graduate School of Life and Environmental Sciences, Kyoto Prefectural University
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- Aoi Wataru
- Department of Nutrition Science, Graduate School of Life and Environmental Sciences, Kyoto Prefectural University
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- Kuwahata Masashi
- Department of Nutrition Science, Graduate School of Life and Environmental Sciences, Kyoto Prefectural University
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Abstract
<p>We recently reported that dietary cystine maintained plasma mercaptalbumin levels in rats fed low-protein diets. The present study aimed to compare the influence of low-protein diets supplemented with cystine and methionine, which is another sulfur amino acid, on plasma mercaptalbumin levels in rats. Male Sprague–Dawley rats were fed a 20% soy protein isolate diet (control group), 5% soy protein isolate diet (low-protein group) or 5% soy protein isolate diet supplemented with either methionine (low-protein + Met group) or cystine (low-protein + Cyss group) for 1 week. The percentage of mercaptalbumin within total plasma albumin of the low-protein + Met group was significantly lower than that of the control and low-protein + Cyss groups. No significant differences in the mRNA levels of tumor necrosis factor-α, interleukin-6, interleukin-1β, and cyclooxygenase 2 in blood cells were observed between the low-protein + Met and low-protein + Cyss groups. Treatment with buthionine-(S,R)-sulfoximine, an inhibitor of glutathione synthesis, did not influence the percentage of mercaptalbumin within total plasma albumin in rats fed the low-protein diet supplemented with cystine. These results suggest that supplementation with cystine may be more effective than that with methionine to maintain plasma mercaptalbumin levels in rats with protein malnutrition. Cystine might regulate plasma mercaptalbumin levels via the glutathione-independent pathway.</p>
Journal
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- Journal of Clinical Biochemistry and Nutrition
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Journal of Clinical Biochemistry and Nutrition 69 (2), 122-130, 2021
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Details 詳細情報について
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- CRID
- 1390007757212838912
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- NII Article ID
- 130008082422
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- ISSN
- 18805086
- 09120009
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- Text Lang
- en
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed