Impact of Ossification Expansion on Cervical Spine Function in Patients with Ossification of the Posterior Longitudinal Ligament: A Prospective Nationwide Multicenter Study (JOSL CT Study)

DOI
  • Katsumi Keiichi
    Spine Center, Department of Orthopedic Surgery, Niigata Central Hospital Department of Orthopedic Surgery, Niigata University Medical and Dental General Hospital Japanese Organization of the Study for Ossification of Spinal Ligament (JOSL)
  • Hirai Takashi
    Department of Orthopedic Surgery, Tokyo Medical and Dental University Japanese Organization of the Study for Ossification of Spinal Ligament (JOSL)
  • Yoshii Toshitaka
    Department of Orthopedic Surgery, Tokyo Medical and Dental University Japanese Organization of the Study for Ossification of Spinal Ligament (JOSL)
  • Nagoshi Narihito
    Department of Orthopaedic Surgery, Keio University, School of Medicine Japanese Organization of the Study for Ossification of Spinal Ligament (JOSL)
  • Nishimura Soraya
    Department of Orthopaedic Surgery, Keio University, School of Medicine Japanese Organization of the Study for Ossification of Spinal Ligament (JOSL)
  • Mori Kanji
    Department of Orthopaedic Surgery, Shiga University of Medical Science Japanese Organization of the Study for Ossification of Spinal Ligament (JOSL)
  • Takeuchi Kazuhiro
    Department of Orthopedic Surgery, National Hospital Organization Okayama Medical Center Japanese Organization of the Study for Ossification of Spinal Ligament (JOSL)
  • Maki Satoshi
    Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine Japanese Organization of the Study for Ossification of Spinal Ligament (JOSL)
  • Nakamura Masaya
    Department of Orthopaedic Surgery, Keio University, School of Medicine Japanese Organization of the Study for Ossification of Spinal Ligament (JOSL)
  • Matsumoto Morio
    Department of Orthopaedic Surgery, Keio University, School of Medicine Japanese Organization of the Study for Ossification of Spinal Ligament (JOSL)
  • Okawa Atsushi
    Department of Orthopedic Surgery, Tokyo Medical and Dental University Japanese Organization of the Study for Ossification of Spinal Ligament (JOSL)
  • Kawaguchi Yoshiharu
    Department of Orthopedic Surgery, Faculty of Medicine, University of Toyama Japanese Organization of the Study for Ossification of Spinal Ligament (JOSL)

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Other Title
  • 脊柱靭帯骨化の広がりが頚椎機能に与える影響―全国多施設前向き調査・JOSL CT study―

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Abstract

<p>Ossification of the posterior longitudinal ligament (OPLL) is a progressive disease. The bridging of ossified lesions to the vertebral body gradually increases, thereby decreasing the mobility of the cervical spine; thus, cervical spine function may decrease over time. However, cervical spine function in patients with cervical OPLL has not been evaluated in large prospective studies. Therefore, we conducted a prospective multicenter study to clarify whether expansion of ossification can influence cervical spine function and quality of life (QOL) in patients with cervical OPLL. In total, 238 patients (162 men, 76 women; mean age, 63.9 years) were enrolled from 16 institutions in Japan. Each patient underwent whole spine computed tomography and was evaluated based on the Japanese Orthopaedic Association Cervical Myelopathy Evaluation Questionnaire (JOACMEQ). The JOACMEQ can evaluate cervical spine function using the cervical spine function domain (range 0-100 points; normal scale = 100 points). The mean score of cervical spine function was 65.9 points, and neck rotation was the most limited movement compared with flexion and extension. A higher neck VAS score and a larger number of bridge formations of OPLL in the whole spine were significant predictors of adverse outcomes related to cervical spine function. This is the first prospective multicenter study to reveal the impact of ossification expansion on cervical spine function. These findings are important for understanding the natural course of OPLL and can serve as controls when evaluating postoperative cervical spine function.</p>

Journal

  • Journal of Spine Research

    Journal of Spine Research 12 (9), 1087-1093, 2021-09-20

    The Japanese Society for Spine Surgery and Related Research

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