Histochemical characteristics on minimodeling-based bone formation induced by anabolic drugs for osteoporotic treatment
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- YAMAMOTO Tomomaya
- Developmental Biology of Hard Tissue, Graduate School of Dental Medicine, and Faculty of Dental Medicine, Hokkaido University Northern Army Medical Unit, Camp Makomanai, Japan Ground Self-Defense Forces
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- HASEGAWA Tomoka
- Developmental Biology of Hard Tissue, Graduate School of Dental Medicine, and Faculty of Dental Medicine, Hokkaido University
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- FRAITAS Paulo Henrique Luiz de
- Department of Dentistry, Federal University of Sergipe at Lagarto
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- HONGO Hiromi
- Developmental Biology of Hard Tissue, Graduate School of Dental Medicine, and Faculty of Dental Medicine, Hokkaido University
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- ZHAO Shen
- National Clinical Research Center of Stomatology, Department of Endodontics, School of Medicine, Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Ninth People’s Hospital, Shanghai Jiaotong University
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- YAMAMOTO Tsuneyuki
- Oral Functional Anatomy, Graduate School of Dental Medicine, and Faculty of Dental Medicine, Hokkaido University
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- NASOORI Alireza
- Developmental Biology of Hard Tissue, Graduate School of Dental Medicine, and Faculty of Dental Medicine, Hokkaido University
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- ABE Miki
- Developmental Biology of Hard Tissue, Graduate School of Dental Medicine, and Faculty of Dental Medicine, Hokkaido University
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- MARUOKA Haruhi
- Orthodontics, Graduate School of Dental Medicine, and Faculty of Dental Medicine, Hokkaido University
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- KUBOTA Keisuke
- Oral Functional Prosthodontics, Graduate School of Dental Medicine, and Faculty of Dental Medicine, Hokkaido University
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- MORIMOTO Yasuhito
- Periodontology and Endodontology, Graduate School of Dental Medicine, and Faculty of Dental Medicine, Hokkaido University
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- HARAGUCHI Mai
- Developmental Biology of Hard Tissue, Graduate School of Dental Medicine, and Faculty of Dental Medicine, Hokkaido University
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- SHIMIZU Tomohiro
- Department of Orthopedic Surgery, Graduate School of Dental Medicine, and Faculty of Dental Medicine, Hokkaido University
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- TAKAHATA Masahiko
- Department of Orthopedic Surgery, Graduate School of Dental Medicine, and Faculty of Dental Medicine, Hokkaido University
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- IWASAKI Norimasa
- Department of Orthopedic Surgery, Graduate School of Dental Medicine, and Faculty of Dental Medicine, Hokkaido University
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- LI Minqi
- Shandong Provincial Key Laboratory of Oral Biomedicine, The School of Stomatology, Shandong University
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- AMIZUKA Norio
- Developmental Biology of Hard Tissue, Graduate School of Dental Medicine, and Faculty of Dental Medicine, Hokkaido University
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Abstract
<p>Modeling, the changes of bone size and shape, often takes place at the developmental stages, whereas bone remodeling—replacing old bone with new bone—predominantly occurs in adults. Unlike bone remodeling, bone formation induced by modeling i.e., minimodeling (microscopic modeling in cancellous bone) is independent of osteoclastic bone resorption. Although recently-developed drugs for osteoporotic treatment could induce minimodeling-based bone formation in addition to remodeling-based bone formation, few reports have demonstrated the histological aspects of minimodeling-based bone formation. After administration of eldecalcitol or romosozumab, unlike teriparatide treatment, mature osteoblasts formed new bone by minimodeling, without developing thick preosteoblastic layers. The histological characteristics of minimodeling-based bone formation is quite different from remodeling, as it is not related to osteoclastic bone resorption, resulting in convex-shaped new bone and smooth cement lines called arrest lines. In this review, we will show histological properties of minimodeling-based bone formation by osteoporotic drugs.</p>
Journal
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- Biomedical Research
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Biomedical Research 42 (5), 161-171, 2021-09-21
Biomedical Research Press
