Inactivation of SARS-CoV-2 by Catechins from Green Tea

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  • Nishimura Hidekazu
    Virus Research Center, Clinical Research Division, Sendai Medical Center, Japan
  • Okamoto Michiko
    Department of Virology, Tohoku University Graduate School of Medicine, Japan
  • Dapat Isolde
    Virus Research Center, Clinical Research Division, Sendai Medical Center, Japan
  • Katsumi Masanori
    Sendai City Institute for Public Health, Japan
  • Oshitani Hitoshi
    Department of Virology, Tohoku University Graduate School of Medicine, Japan

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Abstract

<p>Green tea extracts effectively inactivated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in vitro in a dose-dependent manner. Ten-fold serially diluted solutions of catechin mixture reagent from green tea were mixed with the viral culture fluid at a volume ratio of 9:1, respectively, and incubated at room temperature for 5 min. The solution of 10 mg/mL catechin reagent reduced the viral titer by 4.2 log and 1.0 mg/mL solution by one log. Pre-infection treatment of cells with the reagent alone did not affect viral growth. In addition, cells treated with only the reagent were assayed for host cell viability using the WST-8 system, and almost no host cell damage by the treatment was observed. These findings suggested that the direct treatment of virus with the reagent before inoculation decreased the viral activity and that catechins might have the potential to suppress SARSCoV-2 infection.</p>

Journal

  • Japanese Journal of Infectious Diseases

    Japanese Journal of Infectious Diseases 74 (5), 421-423, 2021-09-30

    National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee

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