Low Free Triiodothyronine Level as a Predictor of Cardiovascular Events and All-Cause Mortality in Patients Undergoing Hemodialysis: The DREAM Cohort
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- Yamazaki Yuko
- Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine
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- Shoji Tetsuo
- Department of Vascular Medicine, Osaka City University Graduate School of Medicine Vascular Science Center for Translational Research, Osaka City University Graduate School of Medicine
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- Miyashima Masako
- Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine
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- Nagata Yuki
- Department of Vascular Medicine, Osaka City University Graduate School of Medicine Vascular Science Center for Translational Research, Osaka City University Graduate School of Medicine
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- Kakutani Yoshinori
- Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine
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- Ochi Akinobu
- Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine
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- Morioka Tomoaki
- Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine
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- Nakatani Shinya
- Department of Nephrology, Osaka City University Graduate School of Medicine
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- Mori Katsuhito
- Department of Nephrology, Osaka City University Graduate School of Medicine
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- Tsujimoto Yoshihiro
- Division of Internal Medicine, Inoue Hospital
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- Emoto Masanori
- Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine Vascular Science Center for Translational Research, Osaka City University Graduate School of Medicine Department of Nephrology, Osaka City University Graduate School of Medicine
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<p>Aim: Low T3 syndrome is characterized by low serum triiodothyronine (T3) levels without elevation of thyroid-stimulating hormone (TSH) in patients without apparent thyroid disease, which is known to be associated with worse clinical outcomes in various populations including those with kidney failure. In this study, we examined whether low free T3 (FT3) levels are independent predictor of cardiovascular disease (CVD) events in patients undergoing hemodialysis. </p><p>Methods: This was a prospective cohort study of patients with chronic kidney disease undergoing hemodialysis. From the total of 518 patients, we excluded patients with treated or untreated hyperthyroidism or hypothyroidism and those treated with corticosteroids. </p><p>Results: We analyzed data from 438 eligible patients. During the 5-year follow-up, 154 new CVD events and 86 all-cause deaths were recorded. Kaplan-Meier analysis showed that lower FT3 levels were associated with higher risks for new cardiovascular events and all-cause death. This inverse association of FT3 and new CVD events remained significant after adjustment for age, sex, duration of hemodialysis, diabetic kidney disease, hypertension, dyslipidemia, and smoking; however, it was no longer significant after further adjustment for prior CVD or N-terminal fragment of probrain natriuretic peptide (NT-proBNP). FT3 did not show an independent association with all-cause mortality. </p><p>Conclusions: Our results indicate that low FT3 status is not an independent predictor of new CVD events and that the following factors are closely associated: prior CVD, low FT3 and high NT-proBNP levels at present, and future risk of new CVD events in hemodialysis patients. </p>
収録刊行物
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- Ｊｏｕｒｎａｌ ｏｆ Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ ａｎｄ Ｔｈｒｏｍｂｏｓｉｓ
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Ｊｏｕｒｎａｌ ｏｆ Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ ａｎｄ Ｔｈｒｏｍｂｏｓｉｓ 28 (10), 1071-1082, 2021-10-01
一般社団法人 日本動脈硬化学会