Enhanced Vascular Permeability by Microbubbles and Ultrasound in Drug Delivery

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  • Omata Daiki
    Laboratory of Drug and Gene Delivery Research, Faculty of Pharma-Science, Teikyo University
  • Munakata Lisa
    Laboratory of Drug and Gene Delivery Research, Faculty of Pharma-Science, Teikyo University
  • Maruyama Kazuo
    Laboratory of Theranostics, Faculty of Pharma-Science, Teikyo University Advanced Comprehensive Research Organization (ACRO), Teikyo University
  • Suzuki Ryo
    Laboratory of Drug and Gene Delivery Research, Faculty of Pharma-Science, Teikyo University Advanced Comprehensive Research Organization (ACRO), Teikyo University

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Abstract

<p>Ultrasound and microbubbles, an ultrasound contrast agent, have recently increased attention to developing novel drug delivery systems. Ultrasound exposure can induce mechanical effects derived from microbubbles behaviors such as an expansion, contraction, and collapse depending on ultrasound conditions. These mechanical effects induce several biological effects, including enhancement of vascular permeability. For drug delivery, one promising approach is enhancing vascular permeability using ultrasound and microbubbles, resulting in improved drug transport to targeted tissues. This approach is applied to several tissues and drugs to cure diseases. This review describes the enhancement of vascular permeability by ultrasound and microbubbles and its therapeutic application, including our recent study. We also discuss the current situation of the field and its potential future perspectives.</p>

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