Comparison between the Effects of Loxoprofen and Acetaminophen on Postoperative Pain Following Radical Prostatectomy: A Propensity Score Matching Analysis

• Nishimura Fumihiro

  Department of Clinical Pharmacy, Kumamoto Chuo Hospital

• Ushijima Tomoko

  Department of Clinical Pharmacy, Kumamoto Chuo Hospital

• Nojima Masako

  Department of Nursing, Kumamoto Chuo Hospital

• Hamada Shinsuke

  Department of Urology Kumamoto Chuo Hospital

• Hara Kazumasa

  Department of Urology Kumamoto Chuo Hospital

• Hamada Yasuyuki

  Department of Urology Kumamoto Chuo Hospital

• Kadowaki Daisuke

  Faculty of Pharmaceutical Sciences, Sojo University

• Miyamura Shigeyuki

  Faculty of Pharmaceutical Sciences, Sojo University

• Oniki Kentaro

  Division of Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Kumamoto University

• Saruwatari Junji

  Division of Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Kumamoto University

抄録

Non-steroidal anti-inflammatory medications are associated with renal impairment. However, there is little information on whether these medications affect postoperative renal function compared with acetaminophen. The objective of this study was to compare the effects of acetaminophen and loxoprofen, used as postoperative analgesic, effect on postoperative analgesia using propensity score matching analysis. We retrospectively enrolled 328 patients treated with loxoprofen or acetaminophen after open radical prostatectomy between October 2017 and February 2020. We analyzed postoperative pain intensity, the incidence rate of acute kidney injury, drug-induced liver injury, and rate of elevation in serum creatinine after open radical prostatectomy. Eighty-one matched pairs of patients treated with loxoprofen or acetaminophen were selected using propensity score matching analysis. The postoperative numerical rating scale was significantly higher in the acetaminophen group than in the loxoprofen group on postoperative day 5. The use of patient-controlled anesthesia and rescue analgesics was significantly higher in the acetaminophen group than in the loxoprofen group. The loxoprofen group had a significantly higher postoperative increase in serum creatinine than the acetaminophen group on postoperative days 5 and 8. The incidence of acute kidney injury was 4.9% in the loxoprofen group and 0% in the acetaminophen group, while the incidence of drug-induced liver injury was 0% in both groups. Acetaminophen appears to be safer than loxoprofen in terms of effects on renal function. Nevertheless, the number of acetaminophen doses and the dose per dose may need to be increased for patients with significant postoperative pain.

収録刊行物

• Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ

  Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 44 (10), 1427-1432, 2021-10-01

  公益社団法人 日本薬学会

キーワード

• radical prostatectomy
• postoperative pain
• non-steroidal anti-inflammatory drug
• loxoprofen
• acetaminophen

詳細情報

• CRID: 1390571039721041920
• NII論文ID: 130008095787
• NII書誌ID: AA10885497
• DOI: 10.1248/bpb.b21-00215
• ISSN: 13475215
• ISSN: 09186158
• NDL書誌ID: 031713507
• PubMed: 34602552
• Web Site: http://id.ndl.go.jp/bib/031713507
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I031713507
• Web Site: https://www.jstage.jst.go.jp/article/bpb/44/10/44_b21-00215/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2022238069
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
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