Spontaneous Remission of Thrombospondin Type-1 Domain-Containing-Associated Membranous Nephropathy
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- Watanabe Shiika
- Division of Nephrology and Hypertension, Department of Internal Medicine, St. Marianna University School of Medicine, Japan
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- Suzuki Tomo
- Division of Nephrology and Hypertension, Department of Internal Medicine, St. Marianna University School of Medicine, Japan Department of Nephrology, Kameda Medical Center, Japan
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- Han Wei
- Division of Nephrology and Hypertension, Department of Internal Medicine, St. Marianna University School of Medicine, Japan
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- Nakata Mayumi
- Division of Nephrology and Hypertension, Department of Internal Medicine, St. Marianna University School of Medicine, Japan
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- Koitabashi Kenichiro
- Division of Nephrology and Hypertension, Department of Internal Medicine, St. Marianna University School of Medicine, Japan
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- Ichikawa Daisuke
- Division of Nephrology and Hypertension, Department of Internal Medicine, St. Marianna University School of Medicine, Japan
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- Kamijo-Ikemori Atsuko
- Department of Anatomy, St. Marianna University School of Medicine, Japan
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- Koike Junki
- Department of Diagnostic Pathology, St. Marianna University School of Medicine, Japan
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- Shibagaki Yugo
- Division of Nephrology and Hypertension, Department of Internal Medicine, St. Marianna University School of Medicine, Japan
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Abstract
<p>Membranous nephropathy often achieves spontaneous remission. However, there are scarce reports of spontaneous remission of thrombospondin type-1 domain-containing 7A (THSD7A)-associated membranous nephropathy. A 64-year-old female presented with nephrotic syndrome and edema of the lower extremities. We diagnosed membranous nephropathy by kidney biopsy and confirmed positive THSD7A on immunofluorescence using frozen sections; serum THSD7A antibodies were also detected. Thirty-four months after the initial diagnosis, she achieved a spontaneous complete remission without immunosuppressive therapy. With the complete remission, no serum THSD7A levels were detected. In this study, we describe serial examinations of kidney biopsies and serum THSD7A antibodies. </p>
Journal
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- Internal Medicine
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Internal Medicine 60 (19), 3125-3128, 2021-10-01
The Japanese Society of Internal Medicine
