Development of Polymeric Vesicles Containing Biomacromolecules Based on Design of Polyion Complex Coupled with Control of Its Fabrication Process

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  • Kishimura Akihiro
    Department of Applied Chemistry, Faculty of Engineering, Kyusyu University Center for Molecular Systems, Kyusyu University Center for Future Chemistry, Kyusyu University

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  • ポリイオンコンプレックスの設計とその作製過程の制御に基づく 生体高分子包含高分子ベシクルの新展開
  • ポリイオンコンプレックス ノ セッケイ ト ソノ サクセイ カテイ ノ セイギョ ニ モトズク セイタイ コウブンシ ホウガン コウブンシ ベシクル ノ シン テンカイ

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Abstract

Biomacromolecules, such as proteins and oligonucleotides have gathered much attention as next generation’s pharmaceutics. However, for further utilization of such biomacromolecules, novel formulation technologies must be more deeply developed. Considering that many of biomacromolecules are charged polymers, polyion complex vesicles, PICsomes, can be an effective tool for the development of advanced formulation for such biomacromolecules. In the present article, a novel strategy for the fabrication of protein–enriched core inside of PICsomes was reported, together with a stepwise crosslinking method for enhancement of the encapsulation efficiency. Furthermore, novel oligonucleotide–based PICsomes and other type of PICsome–based new formulation, such as incorporation of mesoporous silica nanoparticles and bilamellarized PICsomes, were also discussed.

Journal

  • MEMBRANE

    MEMBRANE 46 (5), 287-293, 2021

    THE MEMBRANE SOCIETY OF JAPAN

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