Development of Biomembrane–mimetic Nanoparticles to Overcome Endothelial Cell Layer for Treating Ischemic Stroke

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  • Fukuta Tatsuya
    Department of Pharmaceutical Health Chemistry, Graduate School of Pharmaceutical Sciences, Tokushima University Department of Physical Pharmaceutics, School of Pharmaceutical Sciences,Wakayama Medical University

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Other Title
  • 脳梗塞部位の血管内皮層突破を目指した生体膜模倣微粒子の開発
  • 特集 日本膜学会膜学研究奨励賞受賞記念講演 脳梗塞部位の血管内皮層突破を目指した生体膜模倣微粒子の開発
  • トクシュウ ニホンマク ガッカイマクガク ケンキュウ ショウレイショウ ジュショウ キネン コウエン ノウコウソク ブイ ノ ケッカン ナイヒソウ トッパ オ メザシタ セイタイマク モホウ ビリュウシ ノ カイハツ

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Abstract

The usefulness of delivery of neuroprotective agents with nano–sized liposomes has been demonstrated for treating ischemic stroke. The strategy was based on permeability increase in the blood–brain barrier (BBB) after the onset of stroke, whereas liposomal entry was still limited. As leukocytes and certain exosomes were reported to be able to pass through the BBB, we hypothesized that liposomes with similar properties to those cells/vesicles can overcome the BBB, which allows for efficient delivery of therapeutic molecules into the brain parenchyma. This review will introduce our recent findings on ischemic stroke therapy using liposomal DDS and about approaches to develop biomembrane–mimetic nanoparticles to overcome brain endothelial cell layer.

Journal

  • MEMBRANE

    MEMBRANE 46 (5), 306-311, 2021

    THE MEMBRANE SOCIETY OF JAPAN

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