Endobronchial Lesions from Disseminated <i>Mycobacterium avium</i> Infection in a Patient with Anti-interferon-gamma Autoantibodies
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- Mochizuka Yasutaka
- Department of Pulmonary Medicine, Seirei Hamamatsu General Hospital, Japan
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- Kono Masato
- Department of Pulmonary Medicine, Seirei Hamamatsu General Hospital, Japan
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- Hirama Ryutaro
- Department of Pulmonary Medicine, Seirei Hamamatsu General Hospital, Japan
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- Oshima Yuiko
- Department of Pulmonary Medicine, Seirei Hamamatsu General Hospital, Japan
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- Takeda Kenichiro
- Department of Pulmonary Medicine, Seirei Hamamatsu General Hospital, Japan
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- Tsutsumi Akari
- Department of Pulmonary Medicine, Seirei Hamamatsu General Hospital, Japan
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- Miwa Hideki
- Department of Pulmonary Medicine, Seirei Hamamatsu General Hospital, Japan
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- Miki Yoshihiro
- Department of Pulmonary Medicine, Seirei Hamamatsu General Hospital, Japan
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- Hashimoto Dai
- Department of Pulmonary Medicine, Seirei Hamamatsu General Hospital, Japan
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- Kimura Toshiki
- Department of Respiratory Medicine, Faculty of Life Sciences, Kumamoto University, Japan
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- Sakagami Takuro
- Department of Respiratory Medicine, Faculty of Life Sciences, Kumamoto University, Japan
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- Nakamura Hidenori
- Department of Pulmonary Medicine, Seirei Hamamatsu General Hospital, Japan
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Abstract
<p>A 78-year-old man was admitted to our hospital with a fever and left chest pain. Computed tomography showed multiple lung nodules, narrowing of the right bronchus intermedius with mediastinal lymphadenopathy, and an osteolytic lesion. Bronchoscopic findings showed rapid progression of multiple polypoid lesions and the bronchial stenosis. A biopsy of the endobronchial lesions revealed non-necrotizing granulomatous inflammation, and a tissue culture identified Mycobacterium avium. An anti-human immunodeficiency virus antibody was negative. Finally, anti-interferon-gamma (IFN-γ) autoantibodies were detected, and the patient was diagnosed with disseminated nontuberculous mycobacterium infection with anti-IFN-γ autoantibodies. Antimycobacterial therapy was effective, and radiographic findings, including the endobronchial lesions, were resolved. </p>
Journal
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- Internal Medicine
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Internal Medicine 60 (20), 3267-3272, 2021-10-15
The Japanese Society of Internal Medicine
